Clopidogrel – a boon for chronic disease patients! Successfully included in the Guangdong Alliance procurement list with quantity

Author: Guo Zhongzhou, Zhujiang Hospital, Southern Medical University

On December 10, @Sina Pharmaceutical News said that recently, Sanofi China announced that the company's two drugs in the field of cardiovascular diseases, the original research clopidogrel and the original research irbesartan hydrochlorothiazide, were successfully included in the guangdong alliance procurement list. The interprovincial drug procurement alliance led by Guangdong Province covers Guangdong, Shanxi, Henan, Hunan, Guangxi, Xinjiang and other provinces, and is currently one of the largest local collection alliances. With the guangdong alliance with volume procurement, patients in the provinces within the alliance will be able to use high-quality original research drugs at preferential prices to meet the growing demand for chronic disease treatment. So what is Bolivar in it?

What is clopidogrel?

The trade name of this drug is Bolivar, which belongs to the antiplatelet drugs in the blood system. You may need to determine the genotype of cytochrome P450 (CYP) 2C19 before medication. If CYP2C19 is identified as a slow-metabolizing type, clopidogrel bisulfate may be less effective and requires a switch to another agent.

What is the mechanism of action of this drug?

This drug is a precursor drug, and its active metabolite can selectively inhibit the binding of adenosine diphosphate (ADP) to platelet P2Y12 receptors and the activation of secondary ADP-mediated glycoprotein GPllb/llla complex, thereby inhibiting platelet aggregation; it can also inhibit platelet aggregation induced by other agonists other than ADP.

What diseases can this medicine be used for?

Clopidogrel hydrogen sulfate has the effect of inhibiting platelet aggregation and is mainly used to prevent atherosclerosis from forming blood clots. Secondary prevention for the following atherosclerotic thrombotic events: recent myocardial infarction (

Note: Your doctor may prescribe this medicine to you for other reasons.

What do you need to know before taking the drug?

1. If you have the following circumstances, you can not use clopidogrel hydrogen sulfate, please tell the doctor of all confirmed diseases and treatment options:

Severe liver damage.

Bleeding, such as peptic ulcer bleeding, intracranial hemorrhage.

2. Clopidogrel bisulfate tablets of some manufacturers contain lactose components. If you are lactose intolerant or deficient in lactase, it is best not to take lactose-containing preparations. Please refer to the manual for details.

3. The safety and efficacy of medication for children under 18 years of age are unclear.

Consult your doctor for pregnant women

4. Pregnant women are best to avoid clopidogrel. If you are pregnant or planning to become pregnant, consult a doctor or pharmacist.

Please stop breastfeeding

5. Clopidogrel may be contained in breast milk after medication, if lactating women take medication, please stop breastfeeding. If you are breastfeeding, please inform your doctor so that a better treatment option can be made.

How to use this medicine?

1. Take with or without food.

2. If you forget to take the medicine, please take it as soon as possible within 12 hours. If it exceeds 12 hours, do not take the drug again, just take the normal dose at the next time you take the drug.

Please do not discontinue the drug without authorization

3. Premature discontinuation of the drug may increase the risk of cardiovascular problems, please use the medication according to the course of treatment under the guidance of the doctor, and do not stop the drug without authorization.

Note: Medication not taken as directed or as directed may affect efficacy and increase toxic side effects.

What should I pay attention to during medication?

Please avoid injuries

1. The hemostasis time during medication may be longer than usual, and it is easier to bleed, please avoid injury.

2. It may be necessary to regularly monitor hemoglobin and hematocrit during medication to assess the effect of medication on you.

3. If you need surgery during medication, please inform the doctor in advance that you are taking clopidogrel. Your doctor may arrange for you to stop the medication 7 days before the procedure.

The following side effects may occur after taking the drug:

1. Common side effects after medication include hematoma, nosebleed, gastrointestinal bleeding, diarrhea, abdominal pain, indigestion, bruising, bleeding at the injection site, etc.

2. Overdose can cause bleeding complications. Platelet transfusion in an overdose of this drug may restore coagulation.

Note: You may have other side effects, if you feel unwell after taking the medication, please see a doctor!

What are the preparations and specifications of this drug?

Clopidogrel bisulfate tablets (in terms of clopidogrel) (1) 25 mg. （2）75mg。 （3）300mg。

How is this medicine saved or disposed of?

Store tightly sealed in a place protected from light or dry.

The above is the original work of the volunteers of the "Drug Safety Cooperation Alliance", if you reprint, please indicate the author and source!

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