It is well known that phototherapy is currently safe and effective for the treatment of vitiligo. These include 308nm excimer lasers and 311 narrow-spectrum UVB ultraviolet light therapy. For patients with large-scale vitiligo, the 308nm excimer laser not only has a small irradiation area but also a high treatment cost. In contrast, 311 narrow-spectrum UVB ultraviolet light therapy makes up for the shortcomings of these two aspects very well, which is undoubtedly a blessing for patients with large-scale vitiligo.
First, what is 311 narrow-spectrum UVB ultraviolet phototherapy
The 311 narrow-spectrum UVB treatment system is a photochemotherapy that removes other wavelengths of ultraviolet light and produces a narrow-spectrum medium-wave ultraviolet light with a wavelength of about 311 nm. It is used to treat skin diseases such as vitiligo.
Second, what are the effects of 311 narrow spectrum UVB whitening
1. Stimulate the activity of tyrosinase
When the melanocytes in the skin absorb UVB energy, they will stimulate the activity of tyrosinase, thereby accelerating the oxidation and aggregation of tyrosinase, and then stimulate the proliferation and migration of melanocytes to achieve the purpose of leukoplakia.
2. Immunosuppressive effect
Patients with vitiligo have activated T cells in the leukoplakia lesions, which can damage melanocytes. 311 narrow-spectrum UVB ultraviolet light therapy can effectively induce activated T cell apoptosis, reduce Langerhans cell antigen, inhibit its activated T cell function, and thus reduce the damage to melanocytes.
3. Cytokine action
311 narrow-spectrum UVB ultraviolet light therapy can activate the relevant cytokines when irradiating the skin, and melanin changes from a reducing state to an oxidized state, and there is a proliferative reaction, so that melanin in the affected area of leukoplakia returns to normal. And through keratinocyte mediation can cause melanocyte division and proliferation at the end of the hair root sheath.
Tips: Whether it is 308nm excimer laser or 311 narrow-spectrum UVB ultraviolet light therapy. Do not get wet for a short time after the light is finished (usually after 6 hours), so as not to affect the light effect. Of course, if you are careless with water, you don't have to worry too much, this will only affect the treatment effect of 311, and there is no other major obstacle.