Volume 2 Issue 6
封面解读
彭敏
The intricate relationship between our bodies and the trillions of microbes living in our guts is essential to our health. However, this partnership isn't without its challenges, as the metabolic processes of bacteria and our own cells can sometimes clash. A new study has uncovered a crucial mechanism that resolves one such conflict, ensuring male fertility in mice. Qing Shang et al. found that certain enzymes in the body are essential for detoxifying acetate, a byproduct of gut bacteria, to prevent it from reaching harmful levels. When these enzymes, ACSS1 and ACSS2, are absent, acetate builds up in the bloodstream, leading to metabolic acidosis. This condition disrupts spermatogenesis, the process of sperm production, resulting in male infertility. This study highlights an overlooked metabolic incompatibility between hosts and microbiota, which deepens our understanding of host-microbiota interactions and opens up new avenues for addressing fertility issues linked to metabolic dysfunctions.
目 录
导 读
1. Unveiling the pioneering work of anthropologist Ting-Liang Woo in the study of Chinese national physique
hLife Recollection | 志业丹青重，恩华雨露霏：中国人类学先驱吴定良
通讯作者：陈巍
文章介绍了中国近代著名人类学家、统计学家、心理学家与教育家，中国体质人类学奠基人吴定良。
引用：
Zhou Z, Bao C, Wang Y, et al. Unveiling the pio ·neering work of anthropologist Ting-Liang Woo in the study of Chinese national physique. hLife 2024;2:263–268.
2. Fecal microbiota transplantation in clinical practice: Present controversies and future prospects
hLife Review | 肠菌移植疗法的应用困境及破局之法
通讯作者：秦环龙、陈启仪
文章结合国际最新临床试验结果和上海十院肠道微生态诊疗中心近万人临床实践数据，开创性提出肠菌移植疗法（FMT）对肠内和肠外疾病的治疗响应规律，系统讨论临床实践中供体、受体和临床因素对患者预后的影响，提出大数据平台解决方案以提高重大慢病患者对FMT疗法的治疗响应。
引用：
Tian H, Wang X, Fang Z, et al. Fecal microbiota transplantation in clinical practice: Present controversies and future prospects. hLife 2024;2:269–283.
3. Reconciling host-microbiota metabolic incompatibility safeguards male fertility
hLife Article | 肠道菌群与宿主代谢的兼容性：揭秘对雄性生育力的影响
通讯作者：彭敏
文章发现宿主关键代谢酶ACSS1和ACSS2通过降解肠道菌群代谢产物乙酸来维持雄性小鼠生殖能力。
引用：
Shang Q, Li Z, Yin N, et al. Reconciling host-microbiota metabolic incompatibility safeguards male fertility. hLife 2024;2:284–295.
4. Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau
hLife Article | 刘超院士研究团队报道蒙古高原人群复杂演化历史及代谢相关遗传调控基础的时空演化轨迹
通讯作者：刘超、胡利平、何光林
基于规模性欧亚古今人群全基因组资源，该研究系统地解析了蒙古高原汉族人群的群体演化历史、生物适应性和医学相关性，揭示了脂肪酸和叶酸代谢相关基因的关键突变在五万年尺度下的时空演化轨迹，发现新石器时代农业相关生业模式转变对代谢基因遗传多样性分布模式的显著影响。
引用：
Li X, Wang M, Su H, et al. Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau. hLife 2024;2:296–313.
5. Heterogeneity and clinical genomics of blaKPC-2-producing, carbapenem-resistant Pseudomonas aeruginosa
hLife Letter | 揭秘产blaKPC-2的碳青霉烯耐药铜绿假单胞菌的异质性与临床基因组学之谜
通讯作者：冯友军
本文报道了KPC-2耐药质粒在碳青霉烯类耐药铜绿假单胞菌（CRPA）中的分布和遗传特征，为研究大陆临床ICU环境中CRPA传播机制提供了重要的基因组学视角。
引用：
Huang M, Liu L, Li X, et al. Heterogeneity and clinical genomics of blaKPC-2-producing, carbapenem-resistant Pseudomonasaeruginosa. hLife 2024;2:314–319.