Idebenone is a synthetic analogue of coenzyme Q10, which has antioxidant and neuroprotective effects, and is often used clinically to improve brain damage caused by chronic cerebrovascular disease and traumatic brain injury. It can also improve subjective symptoms, language, memory loss, mental decline, anxiety, depression and other mental and behavioral disorders. Do you know how to take this medicine and what to pay attention to? The following editor will introduce it to you.
1. What kind of drug is idebenone?
Idebenone is an energy metabolism drug synthesized by Japanese scientists in the 80s of the 19th century, which can improve brain dysfunction by activating mitochondrial function, and can also play a strong role in antioxidant and scavenging free radicals by improving the metabolism of the neurotransmitter serotonin in the brain. Clinically, it is mainly used for the treatment of degenerative diseases of the central nervous system related to oxidative compression and diseases related to mitochondrial dysfunction.
2. What are the indications?
Brain impairment caused by chronic cerebrovascular disease and traumatic brain injury.
It can improve subjective symptoms, language, anxiety, depression, memory loss, mental decline and other mental and behavioral disorders.
▲ Source: Photo.com
3. What diseases can be used for the treatment?
1. Duchenne muscular dystrophy:
Idebenone can significantly improve respiratory function in patients with Duchenne muscular dystrophy.
2. Ryber's hereditary optic neuropathy:
Idebenone has sustained beneficial effects in preventing further visual impairment and promoting vision recovery in patients with Leber's hereditary optic neuropathy.
3. Sequelae of cerebral infarction and cerebral hemorrhage;
4. Vascular and senile dementia;
5. Mitochondrial diseases and hereditary ataxia;
6. Treatment of other diseases:
Mitochondrial encephalomyopathy with hyperlactic acidemia and stroke-like episodes, antifibrosis
▲ Source: Photo.com
4. How does the drug work?
This product is a brain metabolism and mental symptom improvement drug, which can activate brain mitochondrial respiratory activity, improve brain energy metabolism of cerebral ischemia, improve the utilization rate of glucose in the brain, increase the production of ATP in the brain, inhibit the production of lipid peroxide in the brain mitochondria, and inhibit the membrane disorder caused by lipid peroxidation of the brain mitochondrial membrane.
5. How to take it correctly?
Take orally.
adults: 30 mg (1 tablet) three times daily;
Take after meals.
6. What adverse reactions may occur?
The incidence of adverse reactions is about 3%, mainly allergic reactions, rash, nausea, loss of appetite, diarrhea, excitement, insomnia, dizziness, etc. Occasionally, leukopenia and liver impairment are seen.
7. What are the precautions?
1. If you take it for a long time, you should pay attention to check the liver function such as GOT and GPT;
2. The safety of this product for pregnant women has not been completely determined, so it is forbidden for pregnant women;
3. Because this drug can be transmitted to breast milk, lactating women should use it with caution.
Reviewer: Yang Yuanrong, Chief Pharmacist, Department of Pharmacy, Jingzhou Central Hospital, and Xiong Jianqun, Deputy Chief Pharmacist
Author/Editor: Liu Kaifei, chief pharmacist, Department of Pharmacy, Jingzhou Central Hospital