Heilongjiang Net News (Liu Rui, Deng Shuzhe, Reporter Wang Zhongyan) 4 microns is the average thickness of pathological sections, and the daily work of the pathology department revolves around these tiny tissue sections that are as thin as cicada wings. Professor Meng Hongxue, Director of the Heilongjiang Provincial Precision Medicine Center, Director of the Heilongjiang Provincial Key Laboratory of Tumor Pathology, and Director of the Department of Pathology of Harbin Medical University Cancer Hospital, is happy to talk to all kinds of cells in this micrometer, accurately unraveling the mystery of diseases for patients.
After returning to China, he practiced reading films with "sharp eyes"
"Medical knowledge is as vast as the ocean, and the deeper you learn, the more you feel awe of life." Professor Meng Hongxue's real relationship with pathology began when he was admitted to Harbin Medical University in 2001, from undergraduate to doctoral, from a fledgling resident to a discipline leader who now leads the pathology team, and has accumulated rich experience in reading nearly 10,000 pathology reports issued on average every year.
In 2010, Professor Meng Hongxue was given the opportunity to study in Japan to engage in clinical pathology work and research. After graduating with a doctorate, he responded to the call of the country and gave up the opportunity to work abroad, and became a pathologist through the Heilongjiang Provincial Overseas Talent Program introduced to Harbin Medical University Cancer Hospital. For more than ten years, with the microscope and books and literature, Professor Meng Hongxue is willing to be like a gourmet, "This is the charm of pathology." ”
Today, Professor Meng Hongxue leads the team to be active in the field of tumor pathology in China. He has served as the executive director of the Youth Council of the Chinese Anti-Cancer Association, the standing member of the Pathology Committee of the Chinese Anti-Cancer Association, and the member of the Molecular Pathology Group of the Pathology Branch of the Chinese Medical Association. He has won many awards such as the Russian Pacific Science and Technology Award, the Heilongjiang Youth Science and Technology Award, the Heilongjiang Provincial Medical New Technology Achievement, and the Longjiang Craftsman, and has served as an editorial board member of domestic and foreign journals such as Current Pharmaceutical Biotechnology and Chinese Journal of Pathology.
Micron slices carry patients' "joys, sorrows, sorrows" and sorrows
A pathology report makes several families happy and sad, and the pathologist's conclusion is the final word for the patient's next treatment. "Clarify the nature of the disease and guide the clinical precision treatment", this is the goal of Meng Hongxue as a pathologist. He often takes the department as his home and the microscope as his companion, and the yellow of the pathology department is always indispensable in the bright lights of the hospital all night.
Ms. Li, who thinks she is healthy and the pillar of the family, is busy with work all the year round, and she has not cared about the symptoms of acid reflux and belching for many years.
Professor Meng Hongxue observed the oval atypic cells growing in a beam-like and adenoid infiltrative manner under the microscope, and the characteristics of the salt-and-pepper nucleus were visible, which was initially considered to be a neuroendocrine tumor, and at the same time, the differential diagnosis of 3-4 common tumors also appeared in his mind. "In fact, this pathology is the most challenging, the nature and type of tumor are different, and the treatment and prognosis of patients are also very different, in case of misdiagnosis, the impact on patients is immeasurable."
Professor Meng Hongxue confirmed the diagnosis of gastric neuroendocrine tumor NET G2 (type 2) through immunohistochemistry results and nuclear mitogram counting. At the same time, through the biopsy and the patient's gastroscopy report, he thought of the possibility that the patient had a genetic syndrome, and suggested that Ms. Li undergo imaging examination and genetic testing. Eventually, Ms. Li's genetic testing results suggested a MEN1 mutation. After Ms. Li got the report, she held Professor Meng Hongxue's hand tightly and said, "Thank you, Director Meng, I have always thought that I just had gastritis for so many years, but I didn't expect it to be a malignant tumor, thanks to you, I was able to get treatment in time." ”
"Every time I find the real cause of the patient's illness, I am really very gratified, and I feel a sense of accomplishment as a pathologist." There are many similar cases, Professor Meng Hongxue has always adhered to his original intention, through his deep and solid reading skills, his ability to combine the comprehensive research and judgment of the patient's condition, and a high sense of responsibility, to find clues of the disease between microns, and to create a "gold standard" for pathological diagnosis.
Continue to strive to lead the "sustainable development" of the discipline
There are lanterns in front of the guide, not afraid of the mountains and high roads to see the world from afar. When Professor Meng Hongxue first came to work in the Department of Pathology of Harbin Medical University Cancer Hospital, he found that there was still a gap between the hospital's molecular pathology and precision detection and the level at home and abroad, so he investigated the development status and trend of precision medicine at home and abroad, and participated in the establishment of Heilongjiang Precision Medicine Center in 2016. The molecular pathology laboratory of the center has become the only "National Demonstration Laboratory of Pathology Quality Control Center" in Heilongjiang Province, and its molecular pathology testing guides the prognosis and clinical medication of the majority of cancer patients, so that patients can get the most accurate and scientific treatment with the least money.
The trend of ambition is not far away, and the poor mountains are far from the sea, and there is no limit. With the support and help of the older generation of experts in the Department of Pathology, in 2016, the Department of Pathology took the lead in realizing the specialization of pathological diagnosis and the responsibility system of third-level physicians, and established a total of 10 professional subgroups, including breast pathology, gastrointestinal pathology, hematolymphoid pathology, bone and soft tissue pathology, gynecological pathology, urogenital pathology, neuropathology, head and neck pathology, respiratory pathology and molecular pathology. Today, under his leadership, the department has become a regional cancer pathological diagnosis center and a national remote consultation center. In 2023, the department was successfully approved as a national key clinical specialty of pathology.
In 2022, Professor Meng Hongxue led the pathology laboratory to successfully apply for the key laboratory of Heilongjiang Province, and established a high-level research team with tumor pathology as the research direction, and undertook the research work of dozens of topics at the national, provincial and ministerial levels.
Mentors and Friends, Working Hard to Teach "Peach and Plum Garden"
As a young master's and doctoral supervisor, Professor Meng Hongxue often talks with students about life and philosophy in addition to teaching, he said: "The profession gives us a sacred responsibility and mission, and we must shoulder this responsibility. "Professor Meng Hongxue will often organize young doctors to participate in pathological discussions, especially when encountering typical or difficult films, and take them to read and learn as soon as possible. At present, he has trained more than 30 master's and doctoral students, all over the "top three" hospitals across the country.
Live up to the young Lingyunzhi, and the apricot forest is blooming with dreams. With more than ten years of medical practice, Professor Meng Hongxue has felt the colorful life under the microscope with his heart, studied pathology, cared for patients, and interpreted the responsibilities and responsibilities of pathologists in the new era with perseverance and dedication.