引言（来源于ChatGPT）
The research hotspots and future development directions of embryonic stem cells (ESCs) mainly focus on the following aspects:
1. Differentiation control of stem cells
Identification of key factors: the study of how transcription factors and signaling pathways can be used to regulate the differentiation of embryonic stem cells into specific cell types. This is essential for regenerative medicine and tissue engineering.
3D culture technology: using three-dimensional culture method to imitate the natural microenvironment and promote the differentiation of stem cells into functionally mature cells.
2. Tissue Engineering and Regenerative Medicine
Organogenesis: Combining biomaterials and stem cells to develop artificial organs and tissues. This can overcome the shortage of organ transplants.
Therapeutic applications: Explore the potential of ESCs for the treatment of various diseases such as diabetes, heart disease, neurodegenerative diseases, etc.
3. Gene editing technology
Application of CRISPR/Cas9 technology: Gene editing technology is used to genetically modify embryonic stem cells to study gene function and disease models.
Treatment of Inherited Diseases: Development of gene therapy strategies that use ESCs to repair or replace disease-causing genes.
4. Ethical and safety issues in stem cell research
Resolution of ethical disputes: Strengthen the ethical review of the use of embryonic stem cells and explore alternatives to induced pluripotent stem cells (iPSCs).
Immune rejection: To study how to reduce immune rejection that may occur after ESC transplantation.
5. Development of cell therapy
Clinical application: apply ESCs to cell therapy, carry out preclinical and clinical studies, and evaluate safety and efficacy.
Comparison of autologous versus allogeneic cells: To investigate the advantages and disadvantages of using autologous versus allogeneic stem cells to determine the best treatment strategy.
6. Research on the stem cell microenvironment
Interactions between extracellular matrix and stem cells: Investigate the influence of the microenvironment on stem cell behavior, including extracellular matrix components, cell-cell interactions, etc.
7. Decellularized matrix and tissue regeneration
Development of acellular technology: research on acellular treatment methods for native tissues as scaffold materials for stem cell growth and differentiation.
Future directions
- Personalized Medicine: Combining genomics and stem cell technology to achieve personalized engineered cell therapy programs.
- Alternatives to pluripotent stem cells: Focus on the development of other types of stem cells, such as induced pluripotent stem cells (iPSCs), to circumvent the ethical issues of embryonic stem cells.
- Interdisciplinary research integration: Combine bioengineering, materials science, computer science, etc., to promote the development of engineered stem cell applications.
In summary, stem cell research is full of potential, and future development will not only promote the progress of basic science, but also bring new breakthroughs to clinical medicine.
Big data analytics
检索数据库：Medline
检索工具：文献鸟/PubMed
Search date: 2024-10-12
检索词：embryonic stem cell AND China[ad]
1. Overview of the paper
In recent years, 9154 Medline-indexed ESC-related research articles have been published in China, and we analyzed them for big data. Use ChatGPT to learn more about the research hotspots of embryonic stem cells.
2. Active institutions for embryonic stem cell research in China: Hubei Medical University published 276 papers, Zhejiang University (221 papers), Central South University (165 papers), Fudan University (152 papers), Peking University (151 papers), Sun Yat-sen University (138 papers), Tongji University (134 papers), Tsinghua University (132 papers), Northwest A&F University (112 papers), Nankai University (108 papers), Sichuan University (102 papers), etc.
3. Embryonic stem cell research in China: Taihe Hospital published 118 papers, the First Affiliated Hospital of Sun Yat-sen University (60), Zhongshan Eye Center (58), West China Hospital (54), Peking University Third Hospital (50), The First Affiliated Hospital of Zhejiang University (49), Shanghai East Hospital (48), Renji Hospital (42), The First Affiliated Hospital of Zhengzhou University (41), etc.
4. Embryonic stem cell research: Chinese authors published in journals:
从发文来看，发表来自中国胚胎干细胞研究文章数量较多的期刊有PLoS One (IF=2.9) (220篇)、Stem Cell Res (IF=0.8) (215篇)、Stem Cell Res Ther (IF=7.1) (200篇)、Sci Rep (IF=3.8) (137篇)、Biochem Biophys Res Commun (IF=2.5) (136篇)等。
5. Embryonic stem cell research: active scholars and their networks in China
Active experts in embryonic stem cell research in China: Deng, Hongkui, Peking University; Zhou, Qi, Chinese Academy of Sciences; Pei, Duanqing, Westlake University; Xie, Wei, Tsinghua University; Jin and Ying of the University of Chinese Academy of Sciences are active in this research field. There are many more excellent researchers, and it is impossible to list them all due to space limitations.
Limitations of this data analysis:
A. This report is a visual report based on the PubMed database based on the PubMed database, based on the search results of the set search terms, within a limited time and number of documents.
B. The purpose of the big data analysis of the "Literaturebird" analysis tool is to present an overview of recent research in the field and is for academic communication purposes only; There is no ranking significance.
C. The statistical ranking of the results of the "Literature Bird" analysis tool on the active unit, author, etc., and only the number of papers in the unit where the first author's paper is located is counted; That is, after the paper is retrieved and downloaded, only the first author's unit is retained for each paper, and then the number of papers in each unit is counted. When there are different spellings of the same unit, PubMed treats it as two different units. In the same authorship arrangement, only the number of papers published by the first author and the last author is counted. If the author's name has a different spelling, it will be processed by the PubMed search platform according to the different authors.
D. The conclusion of this paper is completely from the "Literature Bird" analysis tool, due to the limitations of search terms, the scope of literature included in the search database and the search time, it does not represent the views of this journal, and the data content is likely to be inaccurate.