note! These 223 kinds of drugs were discontinued and discontinued, and there were "anti-fever miracle drugs"

On April 18 this year, the State Food and Drug Administration issued an announcement that, in accordance with the relevant provisions of the "Implementation Provisions of the Drug Administration Law" and the "Measures for the Administration of Drug Registration", it was decided to cancel the registration certificates of 223 drugs such as rosiglitazone maleate tablets, including many common drugs, such as old friends "antipyretic miracle drugs" metamizole, ibuprofen, oxytetracycline...

For small partners with dysmenorrhea, ibuprofen is an essential medicine, and now ibuprofen can not eat? Don't worry, this article will make an interpretation of this.

The corresponding deregistration certificates for the common drugs that are cancelled this time are

These medicines can not be taken later?

Not.

These drugs are not completely banned, and the certificate of specific drugs is revoked.

For example, ibuprofen, this cancellation is the national medicine quasi-word H46020751, other unannounced batches can still be used normally.

After the approval number of these drugs is cancelled, once the national drug regulatory department announces it, it cannot be circulated and used in the drug market. Relevant pharmaceutical companies can no longer produce, can not be used in medical institutions, pharmacies, the drug regulatory department is not allowed to import, production, sales, use of these drugs, is also the focus of investigation and punishment.

Of course, drugs produced by drug approval numbers that have not been cancelled by the national drug regulatory authorities are still available, that is, similar varieties from other manufacturers can still be bought and used.

Why should I declare the approval number of these drugs to be cancelled?

Mainly the adverse reactions of these drugs are serious.

1. Analgin tablets

In long-term use, it is found that it can cause hemophilia, the incidence rate is about 1.1%, and the serious ones are fatal; it can also cause immune hemolytic anemia, thrombocytopenic purpura and aplastic anemia, the skin can cause urticaria, erythema exudative erythema and other allergic manifestations, and in severe cases, exfoliative dermatitis and toxic epidermolysis can occur. Once these adverse reactions to the blood system occur, the consequences are very serious and even fatal.

2. Ibuprofen tablets

Gastrointestinal symptoms occur in 16% of long-term users, including indigestion, burning sensation, stomach pain, etc., and the above symptoms disappear when the drug is discontinued. Neurologic symptoms such as drowsiness, dizziness, and tinnitus are rare and occur in 1% to 3% of patients. Renal insufficiency can occur in some patients, mostly in people with underlying renal lesions.

3. Pain tablets

On the one hand, it is easy to give people the illusion of "curable diseases" and use it arbitrarily; on the other hand, it can cause serious adverse reactions: individual patients have asthma due to allergies to one of the components; serious is agranulocytosis, thrombocytopenic purpura, aplastic anemia, and even lead to death; long-term application can also damage liver and kidney function; there can also be dizziness, cyanosis, dyspnea and other poisoning symptoms; long-term application may appear dependent.

4. Compound acetylsalicylic acid tablets (APC tablets)

The drug is a combination tablet consisting of aspirin and nonacetine. The main adverse reactions of aspirin are stomach discomfort and peptic ulcer, and severe allergic reactions caused by aspirin can also lead to the death of the drug user; phenacetin can cause renal papillary necrosis, interstitial nephritis and acute renal failure, and may even induce pyeloneurocarcinoma and bladder cancer.

Contraindications to the drug: allergic to aspirin, phenacetin, caffeine drugs, hemophilia, active peptic ulcer, renal insufficiency should be banned. It is contraindicated in infants under 3 months of age.

These antipyretic analgesics are evaluated by pharmaceutical researchers, who believe that there are serious adverse reactions, risks outweigh the benefits, and are responsible for the drug users. Secondly, enterprises withdraw from the market based on the considerations made by their own production efficiency.

Are there alternatives to these medicines?

If you consider the serious adverse reactions of the above drugs, alternatives can also be found.

Fever reduction: children can use acetaminophen, benotyl ester preparations, etc. to reduce fever.

Anti-rheumatic: children over 1 year old can choose diclofenac sodium preparation, children over 12 years old can use nemesulide preparation for rheumatism, etc.

Antipyretic in adults: in addition to acetaminophen, benotoster preparations, but also aspirin preparations.

There are many analgesic and anti-rheumatic drugs in adults: diflunisal, etofenac, naproxen, fenbufen, ketoprofen, oxapazine, celecoxib and so on.

What should I do if I have these batches of medicine at home?

Medical institutions at all levels, community health service stations, rural medical institutions, and pharmacies should implement the provisions on the cancellation of 223 drug registration certificates such as rosiglitazone maleate tablets.

When patients use and purchase drugs, if they can check the batch number of drugs, prevent the risks caused by adverse reactions of drugs, supervise medical institutions, community health service stations, pharmacies, and rural medical institutions not to use and sell drugs that have been deregistered, and the drug user has the right to report to the local drug regulatory department the use and sale of drugs with deregistration certificates.

For drugs that have been cancelled at home, expired drugs, etc., do not throw them away casually, prevent and control pollution of the environment, endanger human health, and hand them over to the drug use and sales department, and the drug regulatory department has long had regulations. At the same time, it also prevents criminals from repackaging and repackaging them, and flowing to the family for the second time.

Moreover, drugs and expired drugs that have cancelled drug registration certificates have been included in the National Hazardous Waste Directory, and the local drug supervision and management department shall supervise the destruction or take other harmless treatment and other measures according to law. (Expert of this article: Zhang Xing, deputy chief pharmacist of Ningxia Zhongwei People's Hospital)

Source/Popular Science China WeChat public account

Photo/ Guangzhou Daily, New Flower City Reporter: Li Bo

Guangzhou Daily Xinhuacheng Editor: Zhao Xiaoman