In the course of treatment of a patient with Parkinson's disease, the doctor may recommend him to take ropinirole tablets. [1] [2]
However, this medication is not suitable for all Parkinson's patients.
This article will detail the indications, contraindications, and precautions of ropinirole tablets to help patients and families better understand the drug. [2]
Indications and contraindications of ropinirole tablets[2]
Ropinirole tablets are mainly used for the treatment of early Parkinson's disease and progressive Parkinson's disease. [1] [2]
For patients with early Parkinson's disease, ropinirole tablets can improve movement disorder symptoms, such as tremors, muscle rigidity, etc.; For people with progressive Parkinson's disease, it can reduce the dose of levodopa, thereby reducing the risk of motor complications. [1] [2]
However, not all patients with Parkinson's are suitable for ropinirole. [1] [2]
For example, patients with hepatic impairment should be used with caution because patients with hepatic impairment may have higher plasma levels and lower clearance due to hepatic metabolism.
In addition, pregnant women, lactating women and those who are allergic to this drug are also prohibited.
Precautions for Ropinirole Tablets[2]
1. Drowsiness: There have been reports of patients taking ropinirole experiencing drowsiness during daily activities such as driving a vehicle, which is very dangerous. [1] [2]
Moreover, it has been reported that these manifestations can not appear until 1 year after treatment. Therefore, if the patient experiences significant drowsiness and drowsiness during daytime activities (eg, during conversation, eating), ropinirole should be gradually discontinued. [1] [2]
If the decision is made to continue using ropinirole, patients should avoid driving or other risky activities.
2. Fainting: Patients with early Parkinson's disease (without concomitant levodopa) and patients with advanced Parkinson's disease (concomitant levodopa) will faint during treatment, sometimes accompanied by bradycardia. [1] [2]
3. Symptomatic hypotension: Dopamine agonists may affect blood pressure regulation, resulting in orthostatic hypotension, and the higher the dose, the more obvious the effect. [1] [2]
Therefore, when treating Parkinson's disease with dopamine agonists, it is important to observe the symptoms of orthostatic hypotension, especially when increasing the dosage. [1] [2]
Patients with Pa should avoid sitting up, lying down, and standing upright suddenly, especially if they are in a certain position for a long time or at the beginning of treatment.
4. Dyskinesia Dyskinesia - Ropinirole can exacerbate the side effects of levodopa and exacerbate existing dyspraxia. [1] [2] Reducing the dose of levodopa can eliminate this side effect. [1] [2]
5. Liver and kidneys: Mild to moderate renal impairment (creatinine clearance 30-50ml/min) does not require dose adjustment. Patients with Para with severe liver and kidney impairment should be treated with caution. [2]
Other considerations
In addition to the above considerations, there are some other things to be aware of. For example, patients should avoid bad habits such as alcohol and smoking while taking ropinirole to reduce the occurrence of adverse reactions. [1] [2]
At the same time, patients should have regular routine blood examinations, liver and kidney function tests and other routine examinations during the period of taking the drug, so as to understand the physical condition and adjust the treatment plan in time.
In addition, patients should pay attention to maintaining good lifestyle and eating habits during the medication to ensure the best treatment effect.
While ropinirole tablets are an effective treatment for Parkinson's disease, they are not suitable for all Parkinson's patients. [2]
Before using the drug, the doctor will assess whether the patient is suitable for ropinirole tablets based on their specific situation and inform the patient of the relevant precautions. [2]
Patients should follow their doctor's advice and pay attention to the relevant matters while using ropinirole tablets to ensure the efficacy and safety of the treatment. [2]
Resources:
1. http://neuro.dxy.cn/article/98036
2.https://baijiahao.baidu.com/s?id=1734237504460154670&wfr=spider&for=pc
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