"Superandrogenic syndrome" fetal mother terminates pregnancy, expert: chimerism is not one fetus eating another, and the high crime rate is a misunderstanding

The official website of Beijing Youth Daily

2024-07-22 17:40Posted on the official account of Beijing Beiqing.com

On July 21, #家属称希望不要妖魔化超雄综合征#话题冲上热搜, the reporter conducted a follow-up interview on this matter. Dr. Jiang from the prenatal diagnosis center of a public tertiary hospital in Chongqing explained the supermale syndrome, she said: "The fetal XYY chromosome is very common, and the vast majority of pregnant women choose to keep this type of baby. ”

The reason for this hot search is that the pregnant woman Ms. Chen (pseudonym) went to the Sichuan Provincial Maternal and Child Health Hospital for prenatal examination this year, and was told on July 2 that the fetus has a large number of Y chromosomes, which is speculated to be XY and XYY chimerism (XYY is what ordinary people call "supermale syndrome"). She posted the matter to social platforms for help on July 14, but she didn't expect that most of the more than 180,000 netizens left messages to persuade her to "beat it off", and some netizens left messages: "Superhero crime rate is very high" and "Born is equivalent to planting a time bomb around everyone".

In the face of many people's "persuasion", at about 11 p.m. on July 20, the family of the person concerned updated the video saying that Ms. Chen had safely completed the pregnancy termination operation.

Regarding the topic of superandrogenic syndrome, the reporter interviewed Dr. Jiang from the prenatal diagnosis center of a public tertiary hospital in Chongqing, and he interpreted the issues that netizens are concerned about.

Ms. Chen (not her real name) decided to terminate her pregnancy. (Network diagram)

Chimerism is not one fetus eating another

Question: In the report of Sichuan Provincial Maternal and Child Health Hospital, it was mentioned: "The number of Y chromosomes in the sample was detected, and it is speculated that XY and XYY are chimeric, or other complex karyotypes". Is this speculation justified?

Dr. Chiang: Of course not. Chimerism, although relatively rare in all kinds of organisms in nature, is a situation that can occur in every living organism. The report does not say that there are twins in the fetus, let alone that one fetus eats the other, but that there are two sets of chromosomal systems in the fetus. One is the normal 46,XY male chromosome system, and the other is the 47,XYY supermale chromosomal system. The coexistence of both systems may be due to the failure of meiosis in the early phase and the error of mitosis in the later stage. If it is the chimerism of XX and XY, it is the familiar intersex person, and the baby of this pregnant woman in Sichuan is the chimerism of the male baby and the supermale syndrome, which is nothing terrible, it belongs to the natural phenomenon of genetics. I have encountered a similar situation in my hospital, and it is possible to encounter it almost every year, XYY superandrogen syndrome is a type that accounts for a relatively large proportion of people with sex chromosome abnormalities.

▲Screenshot of netizen comments

"The high crime rate of hyperandrogenic syndrome" is a misconception

Q: Do people with hyperandrogenic syndrome have a high crime rate? Answer: This is a misunderstanding, in the 60s of the last century, some criminal groups were tested abroad, and it was found that some people with hyperandrogenic syndrome were higher than the normal population, and this sampling was biased. In fact, from the current point of view, the incidence of super-male syndrome is still relatively high, and many normal men do not do an examination or even find out that they have super-male syndrome. Q: What are the adverse effects of hyperandrogenic syndrome? Dr. Jiang: The intelligence of this kind of baby is at the level of a normal person, but the IQ index may be 10~15 points lower than that of male compatriots. However, this situation is actually difficult to distinguish in the general population, and on the whole, intelligence is not greatly affected. As for the tendency to violence, judging from the large sample size of the current population, it (superandrogenic syndrome) only increases the risk of mental and emotional disorders a little bit, such as autism, but these are slight increases and the probability is very low, so the overall risk of intellectual and emotional disorders is not high. The current non-invasive pregnancy test can screen out the baby with hyperandrogenic syndrome, and the screening will be done with amniocentesis for further confirmation. In fact, superandrogenic syndrome is a common sex chromosome variation in the industry.

The vast majority of "supermale babies" are able to live normal lives

Q: Does a fetus screened for hyperandrogenic syndrome need to be terminated in the same way as a fetus screened for Down syndrome? A: Maybe more than 20 years ago, everyone had a biased perception of this (superandrogenic syndrome), thinking that it was a chromosomal disorder, and that it might be irritable and irritable when born, and the number of people who induced labor still accounted for a part of it. However, with the popularization of genetic information in recent years, the vast majority of pregnant women choose to keep this kind of baby. From the perspective of human genetics, this kind of fetus can be integrated into society, work, study and live normally, and the risk will not be significantly increased. From the current genetic information, XYY is a milder and more common variant in sex chromosome abnormalities, and it is also the type with better effects after intervention. In fact, in reality, adults XYY was discovered, and it was generally found that there was an abnormality in fertility and it was discovered when I went to IVF. We found that the vast majority of XYY adult men are not at high risk of affecting fertility, and many of them are working, getting married, and having children, and they have not been checked.

(Dahe Daily Comprehensive Upstream News, Surging News)

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