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In life, insomnia and high blood lipids have become a problem for many people.
Have you ever tried various treatments and never been able to get rid of them?
Don't worry, today I want to introduce you to a miraculous medicine - gamma oryzanol.
Not only can it help you have a restful sleep, but it is also effective in improving blood lipid levels.
Doesn't that sound incredible?
1. What is gamma oryzanol?
Gamma oryzanol, whose scientific name is dimethyl fumarate, is an organic compound found naturally in cereals and certain vegetables.
It is a colorless, tasteless, odorless crystalline powder with the chemical formula C6H10O4.
Gamma oryzanol has good water solubility and can be completely dissolved in water to form a transparent solution.
Gamma oryzanol was first discovered in the 30s of the 20th century and was initially used as a food preservative and antioxidant.
As research deepened, scientists gradually discovered more pharmacological effects of gamma oryzanol, especially in improving sleep and regulating blood lipids.
Gamma oryzanol works mainly through two biological mechanisms:
One is by stimulating the release of γ-aminobutyric acid (GABA), which produces a sedative and hypnotic effect;
The second is to inhibit the absorption and synthesis of cholesterol, so as to achieve the effect of lowering blood lipids. Below we will explore both mechanisms in detail.
Gamma oryzanol can increase the level of GABA in the brain.
GABA is the most important inhibitory neurotransmitter in the central nervous system, which has sedative, anxiolytic, hypnotic and other effects.
Gamma oryzanol promotes the conversion of glutamate to GABA by activating glutamate decarboxylase, thereby increasing the concentration of GABA in the brain.
Clinical studies have shown that oral gamma oryzanol can significantly shorten the time to fall asleep, prolong the sleep time, improve sleep quality, and have a significant improvement effect on insomnia symptoms.
In addition, gamma oryzanol can also inhibit the absorption and synthesis of cholesterol.
Gamma oryzanol lowers blood cholesterol levels by inhibiting intestinal cholesterol absorption and downregulating the expression of hydroxymethylglutaryl-CoA reductase (HMG-CoA reductase), a key enzyme for cholesterol synthesis in the liver.
The results of several clinical trials have shown that taking gamma oryzanol for 4-8 weeks can reduce total cholesterol by 10%-15%, low-density lipoprotein cholesterol (LDL-C) by 15%-20%, triglycerides by 10%-15%, and high-density lipoprotein cholesterol (HDL-C) slightly increase or remain unchanged.
This suggests that gamma oryzanol can effectively improve blood lipid disorders and reduce the risk of atherosclerosis and cardiovascular disease.
At present, gamma oryzanol is sold in the market as an over-the-counter drug, and the common dosage forms are tablets, capsules, and granules.
The usual clinical dose is 0.5 to 1.0 g per day, divided into 2-3 oral doses. Drink plenty of water while taking the drug to reduce gastrointestinal upset.
It is generally recommended to take it continuously for 2-3 months to achieve a good lipid-lowering effect.
As a natural organic compound, gamma oryzanol improves sleep and regulates blood lipids through a variety of biological mechanisms, making it a safe and effective choice for the treatment of insomnia and hyperlipidemia.
However, in addition to these two main functions, what other pharmacological effects does gamma oryzanol have? Let's take a closer look at the benefits of gamma oryzanol.
2. What is the role of gamma oryzanol?
In addition to improving sleep and regulating blood lipids, gamma oryzanol also has a variety of other pharmacological effects, making it have a wide range of clinical application prospects.
Antioxidant and anti-aging is another important function of gamma oryzanol.
Gamma oryzanol is a powerful free radical scavenger that effectively neutralizes excess reactive oxygen species in the body and protects cells from oxidative stress.
Gamma oryzanol can also increase the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in the body, enhancing the body's antioxidant defenses.
Animal experiments have shown that gamma oryzanol can delay the decline of cognitive function and improve the learning and memory ability of aging mice, which may be related to its inhibition of oxidative stress damage in brain tissue.
In addition, gamma oryzanol can also inhibit the degradation of skin collagen and promote the synthesis of collagen, thereby playing a role in anti-wrinkle and freckle removal and delaying skin aging.
Gamma oryzanol also has some neuroprotective effects.
The brain is the organ with the largest oxygen consumption in the human body and is highly susceptible to damage caused by ischemia and hypoxia.
Gamma oryzanol can alleviate nerve damage caused by cerebral ischemia and hypoxia by improving cerebral blood perfusion and increasing oxygen supply to brain tissue.
At the same time, gamma oryzanol can also alleviate neuronal apoptosis caused by excitatory amino acid toxicity and protect brain tissue from further damage.
In an animal model of Alzheimer's disease (AD), gamma oryzanol was able to inhibit the deposition of β-amyloid (Aβ) and alleviate cognitive impairment in AD mice.
This suggests that gamma oryzanol may have certain preventive and therapeutic value for neurodegenerative diseases such as AD.
In addition, gamma oryzanol also helps to improve glucose metabolism and lower blood sugar.
Gamma oryzanol can promote the secretion of insulin, improve the sensitivity of surrounding tissues to insulin, and accelerate the transport and utilization of glucose.
In a mouse model of type 2 diabetes, gamma oryzanol significantly reduced fasting and postprandial blood glucose levels, improved glucose tolerance, and alleviated kidney and retinal complications caused by diabetes.
Epidemiological studies have also found that regular consumption of oryzanol-rich foods is associated with a lower risk of developing type 2 diabetes.
Therefore, gamma oryzanol is expected to become a natural product to assist in the prevention and treatment of diabetes.
Gamma oryzanol also has certain anti-inflammatory, anti-tumor, and immunomodulatory effects.
谷维素可以抑制促炎细胞因子如肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)等的产生，减轻炎症反应。
Gamma oryzanol can also induce apoptosis of tumor cells, inhibit tumor angiogenesis, and enhance the body's anti-tumor immune response, thereby playing an anti-cancer role.
In animal models of colon cancer and breast cancer, gamma oryzanol showed good tumor growth inhibition effect.
In addition, gamma oryzanol can also regulate humoral immunity and cellular immunity, and enhance the body's resistance.
As a natural multifunctional active substance, gamma oryzanol can not only improve sleep and regulate blood lipids, but also has a variety of pharmacological effects such as antioxidant, neuroprotective, hypoglycemic, anti-inflammatory, anti-tumor and immunomodulatory, and is a natural medicine with great prospects for development and application.
However, while enjoying the benefits of gamma oryzanol, there are some things that need to be taken special care to avoid adverse reactions.
3. Four contraindications to taking gamma oryzanol
Although gamma oryzanol has a variety of pharmacological effects and is a relatively safe natural medicine, there are still some contraindications to be aware of when taking it to avoid causing adverse reactions or affecting the efficacy of the drug.
1. Pregnant and lactating women should use with caution
Safety data on gamma oryzanol in pregnant and lactating women are lacking.
Animal experiments have shown that high-dose gamma oryzanol has a certain effect on embryonic development and can cause skeletal deformities. Gamma oryzanol can also be secreted through breast milk, which can adversely affect infants.
Therefore, for the safety of the fetus and baby, pregnant and lactating women are advised to avoid the use of gamma oryzanol or use it cautiously under the guidance of a doctor.
2. Patients with liver and kidney insufficiency need to adjust the dose
Gamma oryzanol is mainly metabolized by the liver, and a small part of the original drug is excreted by the kidneys.
Hepatic and renal insufficiency can lead to the accumulation of gamma oryzanol in the body, increasing the risk of adverse effects.
For patients with mild to moderate hepatic and renal insufficiency, the dose of gamma oryzanol should be appropriately reduced, and changes in liver and kidney function should be closely monitored.
Gamma oryzanol should be contraindicated in patients with severe liver and kidney failure to avoid increasing the burden on organs.
3. Patients with hypotension should use with caution
Because gamma oryzanol has a certain antihypertensive effect, it may aggravate the symptoms of hypotensive patients, causing dizziness, fatigue and other discomforts.
Patients with hypotension should monitor their blood pressure when taking gamma oryzanol, especially at the initial stage and when increasing the dose.
If symptoms of hypotension occur, the dose should be adjusted or the drug should be discontinued.
At the same time, gamma oryzanol may have a synergistic effect when combined with other antihypertensive drugs, and care should be taken to adjust the dose of the two drugs to avoid lowering blood pressure too low.
4. Interactions with other drugs
Gamma oryzanol may interact with certain drugs, affecting the absorption, distribution, metabolism, and excretion of drugs, resulting in increased or decreased efficacy, or increased side effects.
For example, gamma oryzanol can enhance the effect of anticoagulants such as warfarin and increase the risk of bleeding; Combined with cardiac glycosides such as digoxin can cause arrhythmias; Combination with antiarrhythmics such as amiodarone can cause severe heart block.
In addition, gamma oryzanol can also affect the blood concentration of immunosuppressants such as cyclosporine and tacrolimus, which may lead to graft rejection or drug toxicity.
Therefore, it is important to inform your doctor about other medications you are taking at the same time as gamma oryzanol to avoid serious drug interactions.
In addition to the above four contraindications, the following points should be paid attention to when taking gamma oryzanol:
(1) Gamma oryzanol may cause gastrointestinal adverse reactions such as nausea, vomiting, diarrhea, etc., and should be taken after meals when taking the drug, and the dose can be appropriately reduced if necessary.
(2) Gamma oryzanol may cause allergic reactions such as rashes, urticaria, etc., and should be used with caution by those with a history of allergies.
(3) Gamma oryzanol may have central inhibitory effects such as dizziness and drowsiness, and it is necessary to avoid high-risk activities such as driving after taking the drug.
(4) Gamma oryzanol can affect the metabolism of some drugs such as statin lipid regulators and calcium ion antagonists by inhibiting cytochrome P450 enzymes, and it is necessary to pay attention to adjusting the dosage of the two drugs.
Although gamma oryzanol is a relatively safe natural medicine, it is still necessary to follow the doctor's advice, pay attention to the dosage and contraindications when taking it, in order to achieve the best clinical efficacy, while avoiding potential adverse reactions and drug interactions.
If you experience any uncomfortable symptoms, you should seek medical attention in time, and if necessary, stop the drug or adjust the treatment plan.
epilogue
Gamma oryzanol, a miraculous gift from nature, is quietly changing people's lives with its unique pharmacological effects and wide range of clinical application prospects.
Whether it's insomnia or hyperlipidemia, gamma oryzanol can help you break it one by one.
But don't forget, no matter how good "Wei Suxia" is, it also has its weaknesses.
Pregnant women, lactating, hepatic and renal insufficiency, hypotension...... In front of these special groups, gamma oryzanol also had to give in obediently.
There are also those seemingly inconspicuous drug interactions, which are the "fatal point" of gamma oryzanol.
Therefore, making friends with Gamma oryzanol is not a casual thing.
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