The 61-year-old Uncle Wang continued to be plagued by pus and bloody stools for half a year, but he thought that he was suffering from internal hemorrhoids, so he did not pay too much attention.
Until recently, the symptoms of pus and bloody stools became more and more serious, so I went to Heilongjiang Provincial Hospital for medical treatment, and how to know that I was diagnosed with rectal cancer.
After relevant examinations, the doctor clarified the location of the rectal cancer, but considering that Uncle Wang was old, had a history of hypertension and was accompanied by arrhythmias, the risk of surgery was high.
After expert consultation, Director Shen decided to perform minimally invasive surgery for him. Director Shen Jiwei said that laparoscopic minimally invasive surgery is small for patients, more delicate than traditional surgical operations, and the scope of excisable tissue is also relatively large.
The minimally invasive operation took 4 hours and removed a total of 19 lymph nodes in Uncle Wang's body, basically without bleeding. 48 hours after the operation, Uncle Wang was able to defecate and walk on the ground, and has now recovered well and has been discharged from the hospital smoothly.
For a long time, rectal cancer has been ignored by the public because its symptoms are very similar to hemorrhoids. When the symptoms are more serious, go to the hospital for treatment, it is already the middle and advanced stage of colorectal cancer. The cure rate for colorectal cancer in the middle and advanced stages is not high, and the 5-year survival rate is usually less than 30%.
Recently, the news that "animal experiments achieve a cure for colorectal cancer" has received a lot of attention, and even the male star Yin Xiaotian has posted a blog post expressing support, hoping that this experiment can help fathers with rectal cancer.
<h1 class="pgc-h-arrow-right" data-track="34" > 1, 100% cure bowel cancer? New anti-cancer drugs have attracted attention</h1>
The concept of bowel cancer is large and encompasses the entire digestive tract. If the tumor occurs in different places, the symptoms will also be different.
If the tumor occurs in the left half of the colon, the patient may have symptoms such as blood in the stool, abdominal pain, obstruction, and abnormal stool shape. These manifestations are often very similar to other gastrointestinal diseases and do not get the patient to pay attention to it in time. It can be said that colorectal cancer is a disease that is "dragged out".
About 80% of the first-time patients in the clinic have been diagnosed with bowel cancer in the middle or even advanced stage, and some patients with locally advanced stages cannot be surgically removed immediately due to the larger lesion or closer to the anus, so the survival rate of colorectal cancer for 5 years has not been greatly improved.
The treatment study, led by Zhang Jie, a Chinese scientist, an academician of the National Academy of Engineering, gave rectal cancer patients hope.
The team took a novel immunotherapy drug formulation, PNP-R848 (nanoparticles wrapped in the membrane of human platelets), which by activating T lymphocytes in the body, so that the immune cells local to the tumor are in a state of suppression.
At present, the new drug has achieved 100% successful cure of solid tumors for the first time in mouse experiments, and the cured mice have their own cancer immunity.
Zhang Jie said, "At present, the CORAL biomedical team is promoting the standardization and large-scale production of the drug product CE120 to prepare for entering the pre-clinical stage. We hope to get this drug to the front line of cancer as soon as possible. ”
<h1 class="pgc-h-arrow-right" data-track="34" > second, dietary errors are "adding fuel to the fire" of the intestines</h1>
Clinically, it has been clinically shown for many years that a high-fat diet is one of the main causes of colorectal cancer, and has even been called the "catalyst" for colorectal cancer. However, there has not been enough evidence to confirm this claim, and a new study led by scientists at the Salk Institute may give the answer.
A high-fat diet disrupts the balance of intestinal bile acids and triggers hormone signals, which promotes the growth of colorectal cancer.
Researchers have found that high-fat foods increase the specific two bile acids on the gut, and these two bile acids inhibit the activity of a protein called FXR. FXR can send hormone signals to intestinal stem cells, the intestines want to repair themselves, FXR as a "supervisor", can make the repair process slow and orderly. But when bile inhibits FXR, stem cells begin to grow rapidly and accumulate DNA damage.
The risk of high fat carcinogenicity may also explain why rectal cancer is getting younger and younger. Of course, there are many factors that cause colorectal cancer, in addition to a high-fat diet, it may also be related to the following factors:
1. Heredity
Clinically, about 25% of colorectal cancer patients have a family history. If a parent has rectal cancer, their children are more than 8 times more likely to develop bowel cancer than normal people.
2. Obesity
Abdominal obesity, in particular, is one of the factors that independently cause colorectal cancer. Too little physical activity, very much affects colonic motility. Strengthening physical activity can promote colon peristalsis and facilitate fecal excretion, thus achieving the effect of preventing colorectal cancer.
3. Intestinal polyps
Although large intestinal polyps are common and mild anorectal diseases, they are also precancerous lesions. In particular, villoid adenoma polyps have a 25% chance of malignancy, and tubular adenomatous polyps have a malignant chance of about 5%.
4. Anorectal diseases
Patients with chronic intestinal diseases have a more than ten times higher probability of developing colorectal cancer than ordinary people. For example, in patients with ulcerative colitis, about 3% to 5% become cancerous. There are also certain colon diseases such as Crohn's disease, ulcerative colitis, appendicitis, colon adenoma can increase the incidence of rectal cancer.
5. Bad living habits
Some studies believe that smoking can produce long-term, persistent chronic stimulation of the large intestine, which is long-term and generally takes forty years to occur.
Alcohol abuse can also increase the incidence of bowel cancer, alcohol will cause the gastrointestinal blood vessels to dilate, destroy the mucus barrier on the surface of the digestive tract mucosa, and promote the absorption of carcinogens.
<h1 class="pgc-h-arrow-right" data-track="34" >3, high-risk groups, remember these bowel cancer symptoms</h1>
Similar to all cancers, the early stages of colorectal cancer are not typical. Since the large intestine and anus are closely linked, they can be roughly divided into abnormal bowel movements and other manifestations:
1. Blood in the stool
Blood in the stool is the earliest and most common symptom of bowel cancer. Blood in the stool caused by bowel cancer is generally dark red, the amount is small, mostly mucus blood stool, mucus pus blood stool.
2. Stool shape
Changes in bowel habits and stool traits are the main clinical manifestations of most bowel cancers, and changes in bowel habits are mainly manifested as constipation, diarrhea, or alternating between the two. At the same time, due to the influence of the perimeter infiltration of tumor formation and narrowing of the intestinal lumen, changes in the shape of the stool will also be found, such as thinning, flattening, and blood marks.
3. Abdominal pain
Hemorrhoids do not cause abdominal pain symptoms, and because bowel cancer irritates the intestine or forms intestinal obstruction or intestinal perforation, it can cause patients to feel dull pain and tingling.
4. pain, incontinence
pain induced by bowel cancer is generally related to cancer cells infiltrating the canal, and this pain will exist whether it is stool or not.
For people over 50 years of age with a history of colorectal polyps or colorectal cancer, chronic enteritis, long-term alcohol consumption or a high-fat diet, long-term sitting and working, and lack of exercise, colonoscopy is recommended every 5 years; stool occult blood test once a year; and digital examination once a year.
Of course, if you want to prevent the occurrence of tumors, you also need to increase physical exercise. If you insist on physical exercise, while avoiding obesity, you can also activate cells in the body and enhance the body's resistance and immunity. #Rumor Zero Plan ##39健康超能团 #
Resources:
[1] "Pus blood found in bowel movements may be rectal cancer". New Evening News.2019-06-01
[2] 100% cure for colorectal cancer? This new drug is not a dream". China Science Daily.2021-04-06
[3] "Pouring Fuel on Fire!" Cell: A high-fat diet can accelerate the induction of colorectal cancer. BioQuest.2019-02-24
Reproduction without the author's permission is prohibited