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Overview of the condition
Ten years ago, Mr. X's greatest hobby was to eat all over the world. It turned out that there was blood in the stool, and I began to mistakenly think that it was hemorrhoids, and I did not take it seriously, thinking that eating some medicine that defeated the fire could solve it.
However, more than a year has passed and there has been no improvement, which has attracted attention. Results Colonoscopy Tips – Rectal Cancer!
Mr X immediately underwent radical resection of rectal cancer in 2013-7. Postoperative pathology: extensive infiltration of moderately differentiated adenocarcinoma, involving adipose tissue around the rectum, accompanied by extensive lymphovascular infiltration. Tumor metastases can be seen in 5 perirecular lymph nodes with lymphatic vessel and extraintestinal intestinal vein infiltration, with a clinical stage of T3N2aM0 (IIIB). Postoperatively combined with 8 courses of oxaliplatin + Siroda chemotherapy.
Pathology trivia
Although the prognosis of rectal cancer in gastrointestinal malignancies is relatively good, it can be seen from Mr. X's pathological report that the tumor has been widely infiltrated at the time of discovery - cancer cell infiltration is seen in the lymphatic vessels and extraintestinal veins, and 5 lymph nodes have metastasized. Usually, the tumor grows by infiltrating deep into the intestinal wall, where there are abundant lymphatic vessels and blood vessels responsible for lymphatic fluid return and intestinal nutrient exchange. These tubes lead to all parts of the body, and "infiltration" means that cancer cells have appeared in these tiny tubes and migrated outward. Even if radical resection is completed to remove the main lesion, it indicates a higher risk of metastatic recurrence in the future.
The later development of the condition also proves this.
Four years later, in March 2018, Mr. X found 3 nodules in his right lung during a re-examination of chest CT, which was confirmed to be lung metastases for rectal cancer.
Despite repeated treatment according to the usual standard protocol, secondary metastasis of the tumor cannot be avoided.
Only one more round can be repeated – TOMO radiation therapy for lung nodules in April 2018. In January 2019, resection of the remaining lung nodules was performed.
The third transfer came even more unexpectedly! Just nine months later, Mr. X's review of PET/CT revealed another metastase of the rumination lymph nodes. It had to be treated with irinotecan + epitolic + tigiosmo.
After experiencing multiple metastatic relapses, Mr. X was exhausted by several surgeries and chemoradiation. If there is a new transfer, the traditional methods are counted and counted, and eventually they still enter this infinite cycle of treatment mode.
Mr. X was more resistant to accepting such a conclusion. The risk of a fourth metastasis remains, but the body struggles to withstand more surgery and the side effects of chemoradiation. So Mr. X would like new treatment options to choose from.
After searching for information from many parties, Mr. Xu and his family learned about professor Zhang Minghui's NKT technology by Professor Zhang Minghui of Tsinghua University School of Medicine through the recommendation of friends, and inquired in detail about the demonstration cases of NKT cell therapy, especially hoping to try to solve the problem of constant recurrence and metastasis.
After reading Mr. X's medical records, Professor Zhang Minghui made the following analysis and judgment:
1. The patient has completed conventional radical resection to remove the visible lesions, but the infiltration of the vasculature and lymphatic vessels of the pathological results suggests a greater risk of relapse and metastasis.
2. Subsequent multiple metastatic recurrences confirm the risk suggested by the pathological results, but fortunately, multiple metastatic lesions have been eradicated through radiotherapy and surgery. A large amount of tumor burden is reduced, creating a good prerequisite for cellular immunotherapy.
3. Even if there are no visible lesions now, but the risk of new metastatic lesions in patients is still very large, "long one, cut one" is not the way. NKT cell therapy is adapted to a wide range of diseases, using autoimmune cells to kill residual "invisible tumor cells" to reduce the risk of metastasis recurrence. At the same time, there are no major side effects, and it is very friendly to patients.
Mr X decided to adopt NKT cell immunotherapy in January 2021 with a regimen of 1 course/month, and has completed 14 courses of treatment for a total of 10 months (as of 2021.10).
Imagery
Abdominal CT shows postoperative changes in rectal cancer, and chest CT shows postoperative changes after right lung metastatic carcinoma, and visible cords are considered postoperative changes. There was no significant change in the two tiny nodules on the right diaphragm apex; local thickening of the right pleura appeared in the 2021.7 re-examination, and the examination returned to normal in 2021.10, combined with the medical history, considering the change after treatment.
Swelling aspect
Tumor marker changes: 2020.4.27-2020.8.5 No obvious abnormalities were found in the review of CEA. 2020.8.26-2021.5 slightly higher than normal (overall volatility). In September 2021, it increased significantly, and then quickly fell back in October, and continued to observe.
quality of life
In this follow-up, Mr. X returned to normal life and work, due to the adjustment of the dietary structure to be mainly vegetarian, the weight has decreased, but the quality of life and spiritual sleep are good, and the score is 84.5 points.
Conclusion
Mr. X's ten years of anti-cancer experience has shown that repeated recurrence and metastasis of tumors is the norm even after conventional treatment models. Therefore, the most important idea is how to inhibit the activity of cancer cells and avoid the continuous emergence of new lesions.
NKT cell immunotherapy is an important supplement to the traditional treatment model! In particular, relying on the immune system to suppress the "resurgence" of tumors plays a key role.
Our large number of treatment cases also prove this. Let's look forward to Mr. X's tracking report next year!
Popular science knowledge, for reference only, individual patients are subject to clinical treatment.