Why are young people amh low? Is dhea a hormone that gets fat?

Why are young people amh low? Is dhea a hormone that gets fat?

Decreased amh indicates a decrease in ovarian reserve function, amh is secreted by ovarian sinus follicles, it is not affected by the menstrual cycle, and accurately responds to ovarian function. AmH internationally there is no unified standard, normal between 2-8, below 2.0 indicates that the ovarian functional reserve is not good, the ability to conceive is reduced, but there are also cases of pregnancy below 1.0. Therefore, infertility patients, pregnant women over the age of 35, generally routinely measure an amh. Now life is stressful, young girls have many premature ovarian failure, pay attention to life rules, healthy diet. hu

DHEA is a hormonal drug. Eating DHEA generally does not lead to obesity, and weight gain may be related to your own diet and lack of adequate exercise. DHEA is a kind of hormonal substance, which has a good effect on supplementing estrogen in the body, delaying aging, improving sexual function, and improving libido. Especially suitable for menopausal women, menopause body estrogen levels are too low, there will be menopausal symptoms, such as insomnia, dreams, night sweating, vaginal dryness, decreased libido, rough skin and so on. However, the use of DHEA is best used under the guidance of a physician to prevent an imbalance in hormone levels in the body due to overdose.

Many European countries still have considerable restrictions on DHEA, such as in Belgium, the Netherlands, the United Kingdom, Germany, etc., all of which have adopted bans. In 2010, Europe and the United States newly studied DHEAAMH, a derivative of DHEA, France proposed a more convincing research report, DHEAAMH was verified to supplement DHEA, and prevent the genetic variation produced by DHEA, but also has a significant effect on the quality of the ovaries, follicles, eggs and so on.

Since then, based on the safe way to solve the problems of endogenous and exogenous women affecting fertility, the American Endocrine Society, together with the American College of Obstetricians and Gynecologists, the American Society of Reproductive Medicine, the European Endocrinology Society and the International Menopause Society, has appointed a working group to re-evaluate the published factors affecting fertility and issue guidelines for the treatment of the compound pregnancy repair factor DHEA AMH. ANALYSIS OF DHEA AMH: DHEA balances the hormone levels of the preconception mother, and AMH increases the reserve function of the egg.

This is why everyone found that all the PREVIOUS DHEA in North America and Europe, North America, and Europe were removed from the shelves. DHEA AMH is a comprehensive replacement for DHEA.

In 2000, the European Union first proposed, in addition to drugs, to help women with healthy natural pregnancy and test tubes in plant extraction. Subsequently, the United States also proposed that it would work with the European Union to study how to assist in test tubes and natural fertilization. The American Endocrinology Society, together with organizations such as the American College of Obstetricians and Gynecologists, has appointed a working group to consider women's natural pregnancies and ivory tubes from multiple dimensions and systems

Problems with success and embryo quality have issued guidelines for the treatment of THE COMPOUND PREGNANCY REPAIR FACTOR DHEA AMH.

Compound pregnancy repair factor DHEA AMH – egg quality and quantity regulation system

Egg quality and quantity regulation system - replenish ovarian nutrition, repair ovarian function

Analysis of the significance of DHEA AMH: DHEA balances the hormone levels of the preconception mother, and AMH increases the reserve function of eggs.

The age of first childbearing is getting later and later, and more and more women of advanced age are considering childbearing, but the decline in fertility of elderly women is an indisputable fact, so that patients with decreased ovarian reserve function show a trend of increasing year by year, making the proportion of patients with low ovulation response in row IVF - embryo transfer with low ovarian response, it is estimated that 5%-18% of ivory cycles end with low ovarian response. Poor ovarian response will lead to less follicle recruitment, low egg acquisition, especially the small number of high-quality eggs obtained, and a high cycle cancellation rate, so that the pregnancy rate has been seriously reduced has become one of the problems in the field of assisted reproduction.

After the original follicle bank is established, only about 5% of the original follicles initiate recruitment and enter the stage of growing follicle bank, while the vast majority of the original follicles are dormant. In each estrus cycle, when the endocrine environment (mainly referring to gonadotropin secretion) changes, follicles capable of responding to such changes begin to grow faster, a process called periodic recruitment of follicles. There is an obvious obstacle between initiation and periodic fundraising: "The key to whether the follicles that initiate fundraising can participate in cyclic fundraising lies in whether they can cross this barrier, and the decisive role of crossing the barrier is whether the follicles can obtain the ability to respond to FSH.

Studies have found that if FSH is elevated, some follicles are involved in cycle recruitment, otherwise atresia occurs. Adjusting the FSH value is especially important. Clinical treatment with DHEAAMH includes administration of approximately 13 g/day to approximately 26 g/day in human women, and DHEAAMH may have an effect on the number of fertilized oocytes after approximately 4 consecutive weeks. However, DHEAAMH has a significant effect on the number of fertilized oocytes after about 8 weeks or about 2 months of use, and its effect may continue to increase to about four months, and further may continue to be used for more than four months.

Specifically, in 12 women, after at least about 4 months of continuous DHEAAMH treatment, the number of fertilized oocytes produced by women increased significantly, although slight improvements were shown after at least about 4 weeks of continuous DHEAAMH use, and the pairing of fertilized oocytes from women who used DHEAAMH for less than about 4 consecutive weeks with the same woman's fertilized oocytes from DHEAAMH for at least 4 consecutive weeks showed an increase in about 2 fertilized oocytes, Or the median value of about 2.5 fertilized eggs increases the number of oocytes. The number of fertilized oocytes may show a more pronounced increase after at least about 4 months of DHEAAMH treatment and may show the greatest increase after at least about eight months of DHEAAMH treatment. (Why is the amh value low in young people?) Is dhea a hormone that gets fat? ）

AHM reference value description

The normal value of AMH is between 2-6.8ng /ml, the higher the AMH value, the more abundant the egg stock, the longer the golden period suitable for conception, the lower the AMH value, the worse the ovarian function, after the age of 35, the AMH value will begin to decline sharply, when the AMH value is lower than 0.7ng/ml, it means that the egg inventory has been seriously insufficient, almost difficult to conceive.

If the AMH value is greater than 6.8, the constitution of polycystic ovarian syndrome can be considered, and when ovulation injections and drugs are used, the ovaries are also prone to overreact to drugs and excrete too many eggs, resulting in ovarian hyperstimulation syndrome.

AmH checks with the role of test tubes

01 Judgment egg quantity

The determination of AMH indicators can clearly and considerably understand the number of eggs in the ovaries, it can be examined on any day of the menstrual cycle, not affected by the menstrual cycle and hormonal drugs, is secreted by the granular layer cells of the small follicle of the ovaries, can reflect the follicle activity and reserve capacity throughout the life cycle.

The higher the AMH index, the greater the stock of eggs; When the AMH value decreases, it means that the ovaries are aging, in other words, the woman's fertility is declining.

02 Evaluate ovarian function

Nest function decreases as a woman ages, and the quality of the eggs gradually deteriorates.

Especially after the age of 35, the ovarian function will decline sharply, the egg will age, and the probability of chromosomal abnormalities will increase, so that the conception rate will decrease. After the age of 40, ovarian function will be lower.

Through the determination of AMH value, combined with age, the function of the ovaries can be assessed, when the AMH value is between 2 ~ 5ng / ml, indicating that the ovarian reserve is good, too low means that the ovarian function declines, too high is vigilant about whether polycystic ovary syndrome occurs.

03 Estimated IVF success rate

AMH is one of the important indicators for assessing ovarian reserve function and reflecting egg stock, and it is also an important reference for doctors to initially estimate the success rate of IVF.

Decreased ovarian reserve function is the leading cause of difficulty conceiving in women older than 28 years of age. It has been observed that DHEAAMH can improve the number and quality of oocytes and embryos, increase ovarian function, reduce pregnancy rates and reduce the risk of miscarriage. This improves pregnancy outcomes by increasing the rate of high-quality embryos and AMH levels in patients with normal ovarian reserve at an age.

Double-blind randomized controlled studies found no significant change in ovarian AFC in patients supplemented and not supplemented with DHEAAMH, but the number of high-quality embryos increased significantly, possibly due to dheaamh's ability to reduce embryonic aneuploidy. With DHEAAMH intervention, the number of primary follicles, primary follicles and secondary follicles increased significantly, and the follicular atresia improved.

Clinical results show that DHEA supplementation may bring risks, but supplementation with DHEAAMH intensive energy egg sources is too undiscovered, and DHEAAMH and vitamin E supplementation at the same time not only enhance the effect of vitamin E, improve IVF rate and clinical pregnancy rate, but also reduce FSH, increase AFC and AMH, and improve ovarian reactivity. Scientists conducted DHEAAMH experiments on elderly mice, and after a period of quantitative oral DHEAAMH experiments, the number of litters in elderly mice increased, and the survival rate of mice also increased. Through this experiment, it was proved that DHEAAMH not only increases the number of follicles but also improves the quality of eggs. The certification body determined that DHEAAMH has a drug effect but no toxic side effects. (Why is the amh value low in young people?) Is dhea a hormone that gets fat? ）

Effect of low AMH on test tubes

1. The AMH value of IVF expectant mothers is low, and the IVF conception will become slower, and the AMH will decline with the age of IVF women.

Ivy infant premature ovarian failure, stress, unhealthy IVF eating habits, endocrine disorders, GENETIC FACTORS OF IVF, IVF autoimmunity, and even poor IVF lifestyles can affect the ovaries of BOTH AMH and IVF mothers-to-be.

2. Ivy tube baby mother-to-be smoking will reduce the AMH level of IVF expectant mothers and advance the menopause of IVF expectant mothers.

Therefore, for expectant mothers who are preparing to do IVF, they should pay attention to personal hygiene and prepare for ivy in a clean environment.

3, if the AMH value of the expectant mother is low, the IVF expectant mother should not worry too much, it does not mean that the IVF expectant mother is more difficult to get pregnant than others, it is recommended to work and rest on time and develop good living habits.

What aspects should be noted in patients with low AMH values

1. Make good use of each egg

Patients with low AMH promote ovulation with microstimulation, which places less burden on the ovaries and is able to obtain fewer but better average quality eggs.

2. Scientific regulation and guidance intervention

Studies in recent years have found that male hormones can enhance the expression of follicle-stimulating hormone (FSH) receptors in the ovaries, improve the sensitivity of ovarian granule cells to FSH, increase the number of eggs obtained, improve embryo quality, and thus improve the chances of female assisted reproduction.

3. Normal work and rest, healthy life

During pregnancy, we must pay attention to maintaining adequate sleep, reasonable diet, scientific supplementation of nutrition, and emotions have a great impact on cycle ovulation, and we must pay attention to the regulation of emotions.

In recent years, foreign studies have found that DHEA AMH can repair the ovaries, provide ovarian nutrition, improve ovarian reserve function, reduce chromosomal aneuploidy, improve embryo quality, reduce miscarriage rate and cycle cancellation rate, thereby improving clinical pregnancy rate.

In a randomized controlled study of DHEA AMH, 65 patients who took DHEA AMH pre-metallurgical therapy were taken as the study group on a pro-excitation basis, and 48 patients who did not take DHEA AMH were used as the control group. Before the ivy cycle, the patients in the study group took DHEA AMH (French ACMETEA Company, 13 g/pack) 13 g/sachet 2 times a day, and the basal endocrine was reviewed monthly, and if they were unwell, they could stop oral administration and continue to use it after normal.

All patients in the study group underwent DHEA AMH treatment for 3 months before and after taking the cycle, measured the basal endocrine on the third day of menstruation, and counted the number of sinus follicles in both ovaries in parallel B ultrasound. After the cycle, according to the test tube routine, when the dominant follicle > 18 mm, HCG is injected, the eggs are retrieved after 36 hours, inseminated after 4 hours, and fertilization is evaluated after 20 hours.

After taking DHEA AMH in the research group, the basal FSH decreased significantly and the basal AFC increased significantly, AFC is one of the accurate and reliable indicators of ovarian reserve function, experimental data show that DHEA AMH can increase the number of fertilized oocytes and embryos in patients with poor ovarian function, and can improve the quality of oocytes and embryos. The results of this study are combined with a number of studies at home and abroad: DHEA AMH provides the necessary nutrition for the ovaries, achieves the repair of the ovaries, can improve the ovarian reserve function, improve the quality of the embryo, and thus improve the outcome of pregnancy in the IVF cycle.

In the case of the inability to use DHEAAMH, scholars have to perform hyperovulation stimulation through high doses of ovulation-stimulating drugs, which in most cases are expensive and low-response, and the clinical effect is uncertain, while increasing the number of ovulations by applying DHEAAMH has been recognized as an increase in pregnancy rates.

Final conclusion

At the end of the day, no laboratory test is as meaningful as age, and a 30-year-old fairy is more likely to be much better than a 40-year-old fairy even if the AMH is one order of magnitude lower.

If the 40-year-old fairies grasp, grasp, and hold on, today is better than tomorrow! In short, it is better to be famous early, the same is true for test tubes/frozen eggs, laboratory tests are only references, and early is king! (Why is the amh value low in young people?) Is dhea a hormone that gets fat? ）