Autumn is a special birthday celebration in September
Held at Peking University Third Hospital
Celebrated ten years ago
A life like no other
The first in the world
High-throughput sequencing by MALBAC genome amplification
IVF for screening for monogenic genetic diseases
Born here
Her arrival
It not only brings happiness and joy to a small family
It also marks the mainland assisted reproductive technology
It has realized the leap from following to leading
The first "MALBAC-Baby" took a group photo with the research team on its 10th birthday
The story begins at the end of 2010. With the support of his alma mater, Peking University, Xie Xiaoliang, a well-known biophysical chemist and then Mallinckrodt Professor at Harvard University, cooperated with two professors of Peking University, Su Xiaodong and Huang Yanyi, to establish the "Biodynamic Optical Imaging Heart", which was later renamed the "Biomedical Frontier Innovation Center" (BIOPIC).
Since then, Xie Xiaoliang, who has served as the director of the center, has begun to travel frequently between Peking University and Harvard, bringing the world's most cutting-edge scientific and technological concepts and experience back to his homeland. When he was a postdoctoral fellow at the University of Cambridge, he pioneered single-cell transcriptome sequencing technology, and he became the first young talent brought in by the center from overseas.
2010 BIOPIC Inauguration Ceremony
According to Peking University, Xie Xiaoliang's research team was conducting cutting-edge research in genomics at Harvard. Together with his postdoctoral fellow Zong Chenghang and doctoral student Lu Sijia, he invented a new single-cell gene amplification technology, MALBAC, which is multiple annealed circular cycle amplification method.
This technology makes clever use of the principle of quasi-linear amplification, requiring only a single cell to complete high-precision, high-coverage whole-genome sequencing.
Qiao Jie is a well-known expert in reproductive medicine in mainland China. For many years, she has been engaged in clinical and basic research related to obstetrics and gynecology and reproductive health. With the addition of Tang Fufei and Qiao Jie's team, the MALBAC technology invented by Xie Xiaoliang's team has quickly moved from the laboratory to the clinic. At the end of 2013, the results of their new collaboration were published in the journal Cell, showing for the first time the possibility of MALBAC technology in the clinical application of IVF.
In early 2013, a letter from Beijing caught Xie Xiaoliang's attention. The person who wrote from the letter suffers from hereditary multiple exophytic bone warts (HME) and has to be removed every three or five years due to chondroma hyperplasia since he was a child, and he is in agony. The cause was a single-base mutation in his EST1 gene, which was inherited through the paternal line. His wife, who is 36 years old, has a normal genome but a higher chance of chromosomal copy number abnormalities in egg cells.
In order to give birth to a healthy child, the couple consulted countless information, visited famous doctors at home and abroad, and did not give up hope even if they ran into walls everywhere. When the MALBAC technology was introduced, they rushed to the news in the hope that this state-of-the-art embryo genetic diagnosis technology would help their family realize their dreams.
The couple became the family of clinical trial case No. 1. Lu Sijia's team from Yikon Genomics also joined the project, working with the teams of Xie Xiaoliang, Tang Fufei and Qiao Jie to apply next-generation sequencers and precision single-cell genome amplification technology to preimplantation embryo screening in vitro fertilization, and developed a "triple diagnosis" MARSALA technology that can simultaneously detect pathogenic gene loci, aneuploidy and linkage analysis.
On September 19, 2014, the world's first IVF was successfully born for single-gene genetic disease screening by MALBAC genome amplification high-throughput sequencing.
"MALBAC-Baby" ultrasound in the fetal period
September 19, 2014, World Head of Representative "MALBAC-Baby"
庆祝“MALBAC-Baby”十周岁生日留念
The birth of MALBAC-Baby in 2014 marked the breakthrough of PGT-M from "zero" to "one" in the Department of Reproductive Medicine of the Third Hospital of Beijing Medical University, which is a perfect example of the combination of basic scientific research and clinical application.
So far, as a model of the combination of industry, academia, research and medicine, MARSALA technology has been promoted to more than 110 units around the world, blocking the intergenerational transmission of more than 1,200 disease-causing genes, testing more than 12,000 families, and helping about 6,000 families with genetic diseases to realize their desire to have healthy babies.
At the birthday party, the scientific research team and medical staff who created a miracle together reviewed the extraordinary journey with the little birthday star and her parents, and sent the most sincere and good wishes to the child.
The research team, family and friends wish the poem "MALBAC-Baby": Qiu Ya celebrates her birthday
Xie Xiaoliang was deeply pleased to see the healthy growth of the child. "'MALBAC-Baby' has become a successful example of precision medicine," he said, "The revolution in high-throughput DNA sequencing technology has brought new opportunities for biomedical development. I am glad that I have caught the dividends of this technological revolution and achieved world-leading results in my first attempt to apply single-cell expansion technology to reproductive medicine clinics. ”
It was inspired by this that Xie Xiaoliang made the decision to return to China full-time in 2018. BIOPIC officially changed its name to "Biomedical Frontier Innovation Center". He firmly believes that at Peking University, he can do world-leading work at BIOPIC and that it is his mission as a scientist to benefit mankind, as well as the greatest happiness and satisfaction.
Netizen: Thank you to those who are committed to the healthy development of mankind and continue to work hard
(Integrated Peking University Convergence Media Center, Peking University Health Science Center, Peking University Third Hospital, Peking University Biomedical Frontier Innovation Center)