Content Sources:
1. Zhao Li. Clinical efficacy and pharmacological analysis of rosuvastatin and atorvastatin in the treatment of patients with coronary heart disease and hyperlipidemia[J].Journal of Contemporary Medicine,2024,22(10):93-96.)
2. Li Shunqing, Zhao Quanlin. Liaoning Journal of Traditional Chinese Medicine,2024,51(1):216-220.
3. Wu Zhongqi. Journal of Practical Rural Doctors in China,2022,29(7):14-15.
In 2018, 50-year-old Liu Changqiang, who lives in Shanxi, is a warehouse manager, and his daily job is to move, count, and record goods. In order to relieve boredom, he often sat with his colleagues and chatted and played cards, and smoked cigarettes one after another, and the whole warehouse was full of smoke. Liu Changqiang has been a smoker for more than 20 years, and except for the occasional dry cough, he has no other physical discomfort, so even if his family dissuades him, he has never thought of quitting smoking.
On May 20, a new batch of goods arrived in the warehouse, and everyone went to move them. Liu Changqiang also hurriedly stepped forward, who would have thought that he didn't lift it for a while, he shook his numb hand, and it took a lot of effort to move. After a few back and forth, he felt numbness in his hands, muscle tension, and a throbbing pain in his calves, he hurriedly stopped, limped to find a place to sit, gently kneaded the cramp just now, moved his lower limbs, and the discomfort was relieved for several minutes.
In the middle of the night, the calf began to cramp again, the muscles twitched and twitched, the pain made Liu Changqiang wake up from his sleep in an instant, and couldn't help but scream, the wife who was woken up massaged his calf distressedly, and said that it may be caused by calcium deficiency, and went to the pharmacy early the next morning to buy calcium tablets, after a week of treatment, Liu Changqiang's cramps never happened again, and he didn't take this episode to heart.
In June 2018, gradually entering the summer, Liu Changqiang felt dizzy from time to time, like a lid buckled on his head, heavy and uncomfortable, on the 18th, the temperature in Shanxi was 36 °C, and the only electric fan in the warehouse could not drive away the heat waves, like a steamer, Liu Changqiang sat still and sweated and kept flowing down, just stood up and prepared to go out to breathe the air, the chest suddenly stabbed, the pain was not obvious, like a needle pricking the heart, and even the entire left upper limb was numb, but he only thought it was caused by the weather being too hot. It would be nice to wait until the summer is over.
Next, Liu Changqiang felt dizzy at work every day, but also felt panicked and stuffy in his chest, and even his breathing became a little difficult. Time flies, and in a blink of an eye, it is September, although the temperature is dropping gradually, Liu Changqiang's dizziness and chest tightness still occur from time to time. On September 30, because of the National Day scheduling problem, Liu Changqiang and the warehouse supervisor had a big quarrel.
During the quarrel, the supervisor pushed Liu Changqiang, the dizzy Liu Changqiang did not stand firmly, instantly fell to the ground, anger surged up from the bottom of his heart, he just wanted to stand up, but suddenly felt a sharp pain in his chest, as if there was a boulder in the chest kept hammering, Liu Changqiang curled up on the ground with a painful face, the green tendons on his neck were exposed, and his forehead was also covered with a layer of fine cold sweat, he felt frightened, and even felt that life was passing by a little. Seeing this, the supervisor panicked and quickly dialed 120 to take him to the hospital.
The admission ECG showed ST-segment horizontal depression and T-wave inversion; Coronary CT imaging showed diffuse plaque in the proximal and middle of the left main artery-left anterior descending artery, moderate to severe stenosis in the local lumen of the proximal left anterior descending artery, with the narrowing degree >75% in the narrower part and mild stenosis of the remaining lumen (about 30-50% stenosis). Liu Changqiang's blood biochemistry showed that the serum total cholesterol had reached 7.84mmol/L, and the low-density lipoprotein had reached 5.41mmol/L.
The doctor said that although Liu Changqiang's eating habits are quite healthy, his habit of smoking and drinking is an important risk factor for the disease, and he must quit smoking and limit alcohol after returning home, otherwise his condition is likely to continue to worsen, and even cardiovascular and cerebrovascular accidents such as myocardial infarction and cerebral infarction will occur. LDL cholesterol in the body is often referred to as "bad cholesterol". Because LDL can enter the cells of the arterial wall and bring cholesterol, when there is too much LDL, it will carry cholesterol to be deposited on the arterial blood vessel wall, causing arteriosclerosis and plaque formation, increasing the risk of cardiovascular disease, and smoking and drinking will increase the LDL in the body.
Considering Liu Changqiang's condition, the doctor prescribed lipid-lowering drugs, rosuvastatin is a commonly used lipid-lowering drug in clinical practice, which achieves the purpose of lowering cholesterol by inhibiting the key enzyme HMG-CoA reductase in the process of cholesterol synthesis, and has a significant effect on the removal of low-density lipoprotein, thereby stabilizing arterial plaque and reducing the occurrence of cardiovascular and cerebrovascular accidents. After listening to this, Liu Changqiang deeply realized the severity of hyperlipidemia, and also realized the serious harm of smoking and drinking to the body, and after three months of hard work after returning home, he finally said goodbye to cigarettes and alcohol, supplemented by treatment, and the symptoms of chest tightness and chest pain gradually disappeared.
The day of the re-examination came as scheduled, Liu Changqiang confidently greeted the results of his efforts, and sure enough, he did not disappoint, his blood lipid level has reached 5.82mmol/L, just around the normal level, and the doctor said that there were no symptoms of chest discomfort, indicating that the condition of coronary heart disease is also stable. Liu Changqiang is very happy, as long as he insists, his blood lipids will definitely return to normal.
On March 7, 2019, Liu Changqiang was bored with his colleagues sitting in the warehouse chatting, I don't know what's going on, he felt that the root of his tongue was numb and hard, and his speech was a little unfavorable. All kinds of abnormalities made Liu Changqiang suspicious, and he wanted to go to the hospital for a check-up on his day off.
But on March 8, when counting the goods, Liu Changqiang instantly felt that the world was spinning, there was a sharp pain in his head, his eyes suddenly went black, and he fell straight down, making a "bang" sound, and his colleagues heard the sound and hurriedly came to check, and found that Liu Changqiang was drooling at the corner of his mouth, and he collapsed to the ground unconsciously, and his colleagues immediately dialed 120 to send him to the hospital urgently.
Arrived at the hospital, Liu Changqiang, who had done a head CT scan, suddenly had no pulse, heartbeat and spontaneous breathing, and the doctor sent him to the emergency room for rescue non-stop, and the family members at this time were also waiting anxiously outside, after rounds of cardiopulmonary resuscitation, Liu Changqiang still could not be snatched from the hands of death, and the doctor declared the rescue unsuccessful. After hearing this, the family members couldn't stop crying, and the wife was even more emotionally broken, and rushed directly to the hospital bed to wake up Liu Changqiang.
At this time, the CT results of the head also came out, showing a cerebral hemorrhage in the left frontoprietal lobe; Subarachnoid hemorrhage in both cerebral hemispheres. The doctor said it was a sudden death caused by a cerebral hemorrhage. Somehow, this sentence suddenly angered his wife, and she yelled at the doctor, "There must be something wrong with your medical skills!" My husband wants to be healthy, since he was diagnosed with hyperlipidemia, he has been insisting on treatment, quitting smoking and drinking, eating lightly, and said that his condition is getting better, why did he suddenly have a cerebral hemorrhage? Still died suddenly? How did you rescue it? ”
The doctor lamented: "We have done our best, the probability of death from acute cerebral hemorrhage is as high as 70%, please mourn!" At the same time, the doctor was also puzzled, if what his wife said was true, then what was the cause of Liu Changqiang's sudden death from cerebral hemorrhage? With doubts, the doctor inquired in detail about Liu Changqiang's daily habits, and finally found out the culprit.
The doctor couldn't help but shake his head and said, "Confused! Cerebral hemorrhage did not find him for no reason, although he did not smoke or drink, lived a healthy life, and insisted on treatment, which could indeed prevent the disease from worsening, but he made two fatal mistakes in his diet when using rosuvastatin, which not only did not have any therapeutic effect on the disease, but if he did not pay attention, he would have a heart attack, stroke, and even life-threatening! ”
The first mistake: high-sugar foods
High-sugar foods, such as cakes and milk tea, can cause blood sugar fluctuations and increase the risk of cardiovascular disease. Long-term intake of high-sugar foods may not only cause metabolic diseases such as obesity and diabetes, but also further affect the efficacy of statins. This is because foods high in sugar may alter the pH of the gastrointestinal tract, affecting the solubility and absorption of the drug, in addition to affecting the distribution and excretion of statins in the body, thus affecting the efficacy of statins.
And Liu Changqiang began to quit smoking and drinking after the illness, but it was very difficult, sometimes he was addicted to smoking, he would habitually eat some sugar to relieve his cravings, although he finally quit smoking and drinking successfully, but high-sugar foods had a huge impact on statins. Therefore, while taking statins, the intake of foods high in sugar should be limited.
Second: grapefruit-based foods
Liu Changqiang also has a habit of eating grapefruit, grapefruit does contain vitamins and other rich elements, which are beneficial to people's health, but eating grapefruit foods during the use of statins is indeed a fatal mistake. This is because certain compounds contained in grapefruit, such as furanocoumarins and flavonoids, can affect statin metabolism. These compounds may inhibit the metabolic enzyme CYP3A4 enzyme in the liver, causing statins to accumulate in the body, increasing the risk of side effects. Therefore, grapefruit or grapefruit juice should be avoided while taking these statins.
(Note: "In 18 years, the 50-year-old brother was diagnosed with hyperlipidemia and insisted on taking rosuvastatin for a year, what was the result?") The names of the people are pseudonyms, and some of the pictures are network pictures; Reprinting and plagiarism are prohibited in the article)