【Medical companion travel】Poor selection of toothpaste will induce enteritis? Toothpaste containing this ingredient is best not to choose

Daily care essential daily necessities must include toothpaste, toothpaste as a daily necessities that daily life will contact, its safety problems can not be underestimated, if the choice is not right may damage our body. So what kind of toothpaste can not be chosen? Let's take a look!

Recently, a study published in Nature Communication said that an ingredient called triclosan (TCS) contained in toothpaste may cause damage to the human intestine, which in turn can induce enteritis.

It is reported that triclosan (TCS) is a broad-spectrum antibacterial agent, which is widely used in daily chemicals such as soap, toothpaste, mouthwash, shaving cream, etc., and will also be detected in human breast milk or urine. There are many toothpastes on the market that add triclosan (TCS) to prevent gingivitis.

This study explains why triclosan (TCS) triggers intestinal inflammation and reveals the metabolic activation of triclosan (TCS) by gut microbial enzymes and the mechanism of its enterotoxicity, and these results will help better assess the individual effects of triclosan (TCS) in different populations.

The researchers say that specific gut microbial enzymes linked to TCS promote severe damage in the gut by triclosan (TCS), particularly gut microbiome β-glucuronidase (GUS).

In addition, the researchers found that the concentration of triclosan (TCS) gradually increased from the proximal to distal end of the intestine, and the concentration of TCS-G gradually decreased. Therefore, the researchers believe that there may be some kind of gut microbiota that promotes the conversion of TCS-G into TCS.

To this end, the researchers proposed the hypothesis that "gut microbial GUS intuitous homologs may promote TCS-G to TCS", and finally concluded through experiments that the important promoter of TCS-G to TCS conversion is the Loop1 gut microbiome GUS enzyme.

In addition, in order to alleviate or even eliminate the cologenic effect of TCS in the human body, researchers also tried to target the inhibition of gut microbial GUS enzymes. The final conclusion was that by inhibiting the gut microbiome GUS enzyme it was possible to eliminate the cologenic effects of TCS.

In summary, the study shows that the main cause of enteritis is that TCS is stimulated by intestinal toxicity under the action of human gut microbiome GUS enzymes. However, through the targeted inhibition of the gut microbial GUS enzyme, the harm caused by TCS to the human intestine can be eliminated. At the same time, this study also confirms that toothpaste containing TCS ingredients does cause certain harm to the human body, so when choosing daily necessities, try to avoid using daily necessities containing triclosan (TCS), which is a harmful ingredient!