Good news
近日，西充县人民医院主治医师王鹏在《Cytokine》杂志上发表“Advancements in the study of IL-6 and its receptors in the pathogenesis of gout”的学术论文，主治医师王鹏为文章共同第一作者。 《细胞因子》(Cytokine)是以医学-免疫学综合研究为特色的国际期刊，已被国际重要权威数据库SCI、SCIE收录，期刊聚焦医学-免疫学领域的重点研究和前沿进展。 该刊2023年影响因子为3.7。
△Wang Peng is the first author's signature
The article points out that the oversynthesis of IL-6 and the dysregulation of IL-6R signaling pathway are related to various inflammatory and rheumatic diseases, and are closely related to the pathogenesis of gout, so they are of great significance for the diagnosis and treatment of gout. IL-6 and its receptors, along with their mediated signaling pathways, are involved in a wide range of biological events, including immune responses, acute phase reactions, acute and chronic inflammatory responses, pathophysiology of the gout kidney, uric acid excretion, synovial inflammation, joint destruction, bone erosion, cardiovascular events, and more. This article elucidates the regulatory mechanism of IL-6 and its receptor expression, the molecular mechanism of IL-6 and its receptor function, and the possible role of IL-6 and its receptor signaling pathway in the pathogenesis of gout, providing important insights for understanding the molecular mechanism of gout and developing new treatment options, laying the foundation for clinical trials or research, and providing new options for clinical drug treatment.
△Schematic diagram of IL-6 related research
Doctor's Profile
Wang Peng, a member of the Peasants and Workers Party, a master of medicine, attending physician, graduated from North Sichuan Medical College with clinical medicine and geriatric medicine, and was an outstanding graduate in Sichuan Province. He studied respiratory and critical care, respiratory sleep monitoring, and interventional respiratory medicine at West China Hospital of Sichuan University. He is currently a member of the Rheumatology and Immunology Collaborative Innovation Branch of the Sichuan Medical Science and Technology Innovation Research Association, and a member of the Osteoporosis Special Committee of the Sichuan Diabetes Prevention and Treatment Association. He has published more than 10 papers in Chinese core and SCI journals such as Cytokine, Journal of Clinical Medicine, and Chinese Journal of Rheumatology, including 7 as the first author. He specializes in the diagnosis and treatment of various common and critical diseases in respiratory medicine and geriatrics, especially in the diagnosis and treatment of geriatric-related respiratory infections, sleep disorders, rheumatic immune diseases, etc.
Introduction to the Department of Respiratory and Critical Care Medicine
At present, there are 34 medical personnel in the Department of Respiratory and Critical Care Medicine of Xichong County People's Hospital, including 11 physicians (including 3 master's students, 1 chief physician, 4 deputy chief physicians, and 6 attending physicians), and 22 nurses (including 2 deputy chief nurses, 5 chief nurses, 7 nurses, and 8 nurses). The department is the largest and most technically strong respiratory specialty in Xichong County, and is a municipal key specialty in Nanchong City, a famous department in Xichong County and a tertiary hospital cultivation unit for the standardized construction of the national PCCM department.
Business scope of the department: 1. Respiratory infectious diseases: upper respiratory tract infection, tracheobronchitis, pneumonia, lung abscess, pulmonary mycosis, tuberculosis, etc.; 2. Tracheobronchial diseases: chronic cough, upper airway obstruction, bronchial asthma, chronic obstructive pulmonary disease, bronchiectasis, atelectasis, etc.; 3. Pulmonary vascular diseases: pulmonary thromboembolism, cor pulmonale, pulmonary vasculitis, etc.; 4. Neoplastic diseases: benign and malignant lung tumors and lung metastatic tumors; 5. Pleural diseases: tuberculous pleurisy, pleural effusion, pneumothorax, pleural mesothelioma, etc.; 6. Interstitial lung disease: idiopathic interstitial pneumonia and connective tissue disease related interstitial lung disease; 7. Occupational lung disease: pneumoconiosis; 8. Acute respiratory distress syndrome; 9. Respiratory failure: acute and chronic respiratory failure and mechanical ventilation.
Characteristic diagnosis and treatment techniques: 1. Electronic bronchoscopy and bedside bronchoscopy; 2. Bronchoscopic balloon dilation; 3. Percutaneous lung puncture; 4. Pulmonary function test and bronchodilator test; 5. Exhaled nitric oxide measurement; 6. Mechanical ventilation (invasive and non-invasive). 7. Thoracentesis and thoracostomy.
Contributed by He Mingpei