It is believed that insisting on supplementing 50-250 micrograms of selenium every day can effectively prevent the occurrence of cancer and tumors. Is this true?
The researchers injected a malignant melanoma cell into the blood of mice, and without treatment, the tumor quickly metastasized to the lungs of the mice, but when a certain amount of nanoselene was used, the lung metastasis dropped by 50%-90%. Of course, this is just animal experimentation.
<h1 class="pgc-h-arrow-right" data-track="50" > the world's eight major selenium experiments, and the incidence of cancer was significantly reduced</h1>
So what are some of the major clinical trials? Here are 8 global experiments on the anti-cancer effects of selenium:
One of the experiments came from Qidong, China: Qidong is a high incidence area of liver cancer in China, giving local residents selenium-containing fortified table salt, and residents continued to supplement selenium by about 30-50 micrograms per day for 8 years, resulting in a reduction in the incidence of liver cancer in the region by almost half;
Experiment two from China: The Qidong experience was promoted to ingest 200 micrograms per day in the form of selenium-rich yeast for family members at risk of primary liver cancer. After 2 years, the incidence of liver cancer in the control group (without selenium supplementation) was 1.26%, while the incidence of selenium yeast-rich experimental group (selenium supplementation) was only 0.69%;
The third experiment came from Linxian County, Henan Province, China, which is a high incidence area of esophageal cancer and gastric cancer, from 1984 to 1991, a total of 3698 subjects supplemented with about 50 micrograms of selenium per day, with additional vitamin E and β carotene, which had a moderate inhibitory effect on the mortality rate of esophageal cancer and gastric cancer;
The fourth experiment, from China, promoted the nutrition intervention model in Linxian County, Henan Province, with 29,584 participants taking selenium, vitamin E and β carotene, and the total mortality rate and cancer mortality rate were significantly reduced;
Experiment 5 from China, 3318 subjects with esophageal dysplasia, esophageal dysplasia is a risk factor for esophageal cancer, supplemented daily in dietary form with 50 micrograms of selenium and 14 vitamins and 12 minerals, the results are encouraging after 6 years: cumulative esophageal cancer or cardia cancer mortality rate reduced by 8%;
Experiment 6, from India, was given vitamin A, riboflavin, zinc and selenium daily to 296 subjects, and after 1 year, the frequency of micronucleus in the supplement group was significantly lower than that in the control group (the high frequency of micronucleus suggested that cells were prone to mutation);
Experiment Seven, from Italy, had 304 subjects, given 200 micrograms of selenium, as well as zinc, vitamin A, vitamin C and vitamin E supplementation, and the incidence of heterogeneous adenomas in the experimental group was significantly reduced after 5 years;
Experiment Eight, from the United States, 1312 volunteers had a history of skin cancer, and through selenium-rich yeast supplements, the incidence of lung, colon and prostate cancers was significantly reduced after 4.5 years.
Although the above experiment is not a causal relationship study, it also reflects the effect of selenium supplementation on cancer prevention. Therefore increased selenium supplementation helps for cancer prevention use.
<h1 class="pgc-h-arrow-right" data-track="56" Why can > selenium become the king of cancer? </h1>
It is safe to say that the occurrence of malignant tumors is a class of diseases caused by the interaction of genetic factors and environmental factors, which are closely related to genetic changes in the nucleus. In general, it is divided into two categories, one is the proto-oncogene and the other is the tumor suppressor gene.
Proto-oncogenes refer to oncogenes present in normal cells of living organisms, which are under normal conditions in a state of low expression or no expression, but under certain regulations, such as viral infections, chemical toxicants, radiation effects, long-term stress conditions, etc., proto-oncogenes can be activated and transformed into oncogenes to induce the occurrence of cancer. It must be pointed out that under normal circumstances, proto-oncogenes are not only harmless, but also play an important role in maintaining normal physiological functions and regulating cell growth and differentiation.
The tumor suppressor gene is the opposite of the proto-oncogene, which has positive significance for maintaining the stability of chromosomes and regulating cell proliferation. Inactivation of tumor suppressor genes leads to overexpression of proto-oncogenes, which can induce the occurrence of cancer.
In 2002, a study published in the Journal of the National Academy of Sciences showed that selenium can activate a key tumor suppressor gene, P53, and the activation of the P53 gene can promote the apoptosis of abnormal cells in the body, while hindering the replication of cancer cells to achieve cancer prevention.
<h1 class="pgc-h-arrow-right" data-track="61" > how to supplement selenium is the safest</h1>
In our daily lives, there are many foods rich in selenium. This includes eggs, of which goose eggs rank first, followed by quail eggs, duck eggs, eggs; beans such as soybeans, kidney beans, tofu, etc.; pork, purple potatoes, mushrooms, garlic, nuts, seafood, animal offal are also rich in selenium. In all these foods, the overall selenium content order of food is animal offal> seafood> marine fish> eggs> meat> vegetables> fruits, compared with plant foods, animal foods have higher selenium content.
Selenium supplementation is the safest and most reliable in the form of food supplements, but due to the uncertainty of the dosage of food supplements, appropriate selenium supplements are also needed. However, it must also be noted that too much selenium can also bring physical toxicity. Hospitals can use blood, hair, and urine to learn how much selenium is stored in the body! Once selenium is found to exceed the standard, do not blindly use supplements! Regarding selenium supplementation, we must follow the principle of "how much is missing, how much is supplemented, no shortage is not supplemented, diet therapy is dominant, supplement is supplemented"! Testing of selenium in the body after a period of use of selenium supplements is necessary.