Lao Wang has a history of ulcerative colitis for more than 10 years, from the initial common enteritis, frequent diarrhea, irritable bowel syndrome, to colitis, and finally developed into ulcerative colitis. Some doctors said: The cause of this disease is currently unknown, and it is necessary to take lifelong medication to control the symptoms and prevent the condition from worsening! However, it is a medicine that is poisonous, and taking medicine for a long time is tantamount to chronic suicide! Isn't there a solution?
In recent years, with the rapid development of probiotic medical technology, the world has pinned its hopes on probiotics for the cure of ulcerative colitis.
According to the world's top medical journal "Nature Reviews Microbiology", probiotics control 70% of the body's immunity, digest and absorb 95% of nutrients, and excrete 80% of toxins. Probiotics inhibit the bacteria, viruses, parasites, and pathogens in the intestine to prevent them from harming the intestines, and can build a layer of "bacterial membrane barrier" on the surface of the intestinal mucosa, playing a triple protective effect of "chemical barrier, biological barrier and immune barrier", so that healthy people will not suffer from enteritis.
Whether it is genetic factors, infection factors, environmental factors, mental factors, or autoimmune factors, the onset of ulcerative colitis begins with an imbalance of intestinal flora, harmful bacteria gradually dominate, release a large number of toxins, and produce a large number of free radicals in the intestines, which attack normal immune cells to make them abnormal, and abnormal immune cells in turn attack intestinal mucosal cells, causing inflammation; Immune cells also attack each other, causing an immune response; In the long run, the intestinal mucosa will be congested, edema, ulcers, bleeding, erosion and other conditions, and one of the ideal ways to curb the occurrence of ulcerative colitis at the source is to supplement probiotics with specific functions such as "improving ulcerative colitis" and "scavenging free radicals in the human body".
Many doctors in mainland hospitals also advocate supplementing probiotics for patients with enteritis, and generally prescribe "drug quasi-brand" probiotics, such as: Bifidobacterium quadruple viable bacteria tablets, lactobacillus tablets, Bacillus subtilis double viable bacteria granules, Bacillus licheniformis and other probiotics, Lao Wang has eaten many boxes. Since most of the batch numbers of probiotics are produced before 2006, the strain is single and the safety is unknown, so it needs to be taken under the prescription of a doctor; The strain function, activity, content and other technical indicators of the drug standard brand probiotics are very backward behind some high-end brands of colitis probiotics on the market, and the effect is very limited.
In recent years, the mainland's probiotic medical technology has advanced by leaps and bounds, in view of the fact that it takes nearly five years to apply for a drug name, and it costs nearly 10 million yuan to pass the phase III clinical trial, before it can be approved and listed. Therefore, 99% of the probiotics on the market are food brands, dozens of yuan, more than 100 yuan, more than 200 yuan, more than 300 yuan, more than 400 yuan...... Prices vary widely, and so does quality. Expensive has expensive value, cheap has cheap cat. How can Lao Wang understand this, looking at the dazzling probiotics, all of them are blown superbly, and the psychology of being greedy for cheapness has made Lao Wang take a lot of detours and changed to multiple brands of probiotics, and the final result is the same, it doesn't work!
is still filial to his children, and he bought several expensive imported probiotics for Lao Wang to eat, but the result still didn't work! Later, I heard from people in the industry about the limitations of imported probiotics, and I learned that I had paid the IQ tax again. It turns out that only when probiotics reach the intestine alive and colonize the intestine can they fight against harmful bacteria and play a role in improving the structure of the intestinal flora. However, probiotics are low-end microorganisms and are very picky about the environment in which they live. The strains of bacteria in the intestines of foreigners, the source is unknown, and they are not necessarily suitable for Chinese intestinal survival. Moreover, from abroad to China, its activity will be lost to varying degrees. Therefore, many people in the industry generally do not eat imported probiotics.
Ulcerative colitis has dragged on for a long time, he has eaten too much Western medicine and Chinese medicine, his appetite is getting worse and worse, Lao Wang's body is getting thinner and thinner, and his mental condition is not very good. Lao Wang's temper also became more and more irritable, and he often complained and got angry with his family for no reason. It is still filial piety to children, not only tolerating the father's emotions, but also paying attention to new medical technology products related to ulcerative colitis every day.
Hard-working people, the sky does not pay, the sons and daughters have discovered the "three major invention patent strains independently developed by the mainland, and ulcerative colitis ushers in a new weapon!" With years of experience and lessons, the children did not immediately buy it for their father, but went to the Patent Office of the State Intellectual Property Office to inquire about the patent number and patent details of the three major invention patent strains related to ulcerative colitis, the clinical control test report, and the relevant qualification procedures, formulas, and user feedback of its application product "Huojun No. 1", and the results are as follows:
Patented strain 1: Huojun No. 1 star strain Lactobacillus reuteri JYLB-291
[Invention Name]: A Lactobacillus reuteri JYLB-291 to improve ulcerative colitis and its application (Huojun No. 1)
[Patent No.]: ZL 2021 1 1566079.0
[Certificate No.]: No. 4950492
[Patent details]: In view of the current lack of probiotics with good treatment effect on human ulcerative colitis, the present invention provides a JYLB291 of Lactobacillus reuteri to improve ulcerative colitis and its application (Huojun No. 1), the strain is derived from the feces of healthy adults in China, which is consistent with the application object, and the specificity and effectiveness of the strain to the body's probiotic function are stronger, and it is more suitable for Chinese constitution; When applied, this strain can effectively tolerate gastric acid and bile salts, and colonize the intestine to improve the intestinal microflora and improve the environment for the development of diseases, regulate the balance of pro-inflammatory and anti-inflammatory factors, and thus play a role in improving ulcerative colitis.
[Clinical Trial]: A total of 100 patients with ulcerative colitis whose main symptoms were fecal mucus and pus and blood, abdominal pain, increased stool frequency or loose stools, including 48 males and 52 females, were selected. They were divided into control group and experimental group, with 50 cases in each group. Experimental group: 25 males, 25 females, age 20 ~ 65 years, average age 45.8 years, disease duration 1~10 years, average disease duration 4.8 years, 42 cases with fecal mucus, pus and blood, 35 cases of abdominal pain, 50 cases of increased stool frequency, 47 cases of loose stool.
The experimental group was treated with mesalazine (content 0.4g), 2 tablets/time, 3 times a day; and take Lactobacillus reuteri JYLB291 once daily at a dose of 1×108 cfu/kg body weight.
The treatment time was 30 days, and it can be seen that the treatment effect of the four most typical symptoms (stool mucus and blood, abdominal pain, increased stool frequency, loose stool) was significantly improved after adjuvant treatment with Lactobacillus reuteri JYLB291 1×108 cfu/kg bw/day, and the effective rate was up to 95.7%. In practical application, the JYLB291 of Lactobacillus reuteri added to each bag of Huojun No. 1 is not less than 10 billion cfu, which is much higher than the clinical control test dose of 1×108 cfu/kg body weight.
[Related research]: In the academic journal "Modern Digestive and Interventional Diagnosis and Treatment", Vol. 24, No. 12, 2019, a literature entitled "Probiotic Characteristics of Lactobacillus reuteri and Research Progress in the Treatment of Ulcerative Colitis" has attracted widespread attention. This article discusses in depth the outstanding performance of Lactobacillus reuteri in inhibiting harmful bacteria, regulating intestinal flora, enhancing immune function and improving mucosal barrier, especially in the prevention and treatment of ulcerative colitis.
Professor Hu Naiwen from the Department of Rheumatology and Immunology of Shandong Provincial Hospital further pointed out that Lactobacillus reuteri can not only activate intestinal immune cells and improve the body's ability to resist diseases, but also promote the digestion and absorption of food and reduce the risk of gastrointestinal diseases. In addition, it also has antioxidant function, which can effectively scavenge free radicals and reduce the damage of oxidative stress to the body.
专利菌株二、活君一号明星菌株干酪乳杆菌L.Casei21
[Invention Title]: A Lactobacillus casei L.Casei21 with therapeutic effect on diarrhea and its application (Huojun No. 1)
[Patent number]: ZL 2021 1 0242478.5
Certificate No.: No. 4446831
[Patent details]: In view of the drug resistance and adverse reactions that may be caused by drug treatment, the present invention provides a kind of Lactobacillus casei that has a therapeutic effect on diarrhea. Casei21 and its application (Huojun No. 1), good resistance to gastric acid and bile salts, and strong ability in cell colonization. Casei21 itself can greatly reduce the adhesion effect of pathogenic bacteria, and its metabolites also have a good antibacterial effect on the three pathogenic bacteria of diarrhea, after taking the bacterium can enter the intestine through the digestive tract, inhibit the pathogenic bacteria, and colonize the intestine, maintain the balance of environmental flora, can effectively inhibit the occurrence of diarrhea, improve diarrhea symptoms, and reduce the risk of diarrhea recurrence.
[Clinical trial]: 100 patients with symptoms such as abdominal pain, diarrhea, frequent bowel movements, and warmth in limbs were selected and divided into control group and experimental group, with 50 people in each group, and the trial was conducted for 30 days. During the trial, each patient's living and eating habits remained unchanged, and they all took trimethyl maleate pudding tablets once a day according to the doctor's instructions, and the experimental group took an additional 15 billion Lactobacillus casei L after taking trimethyl maleate tablets for 2 hours. Casei21 once. After 30 days, the efficacy was observed and statistics, and the statistical results are shown in the following table. Casei21 and its products have a clear positive therapeutic effect on patients with diarrhea, with an overall response rate of up to 92%. In practical application, Huojun No. 1 is added with no less than 10 billion cfu per bag of Lactobacillus casei L.Casei21, 2 to 3 bags per day, which is higher than the clinical control test dose of 15 billion.
[Related research]: Professor Qi Dianjun of the First Affiliated Hospital of China Medical University also emphasized that Lactobacillus casei can not only provide the human body with necessary nutrients, enhance nutrient metabolism, but also promote digestion, prevent constipation, further improve intestinal function, and enhance individual physique. More studies have shown that Lactobacillus casei combined with conventional treatment can significantly alleviate the clinical symptoms of patients with ulcerative colitis, with significant efficacy and high safety, which provides a new treatment idea for clinical practice.
Patented strain 3, Huojun No. 1 star strain Bifidobacterium longum JBLC-141
[Invention Title]: A Bifidobacterium longum JBLC-141 that can eliminate free radicals in the body and its application (Huojun No. 1)
【专利号】：ZL 2021 1 0227019X
[Certificate number]: No. 4622441
[Pain point needs]: The theory of free radicals believes that free radicals are the source of all diseases and the main culprits of human immune diseases, aging and tumors. Free radicals attack healthy cells to become senescent cells or cancer cells, free radicals attack immune cells, making normal immune cells abnormal, immune cells attack each other, abnormal immune cells will also attack intestinal mucosal cells, over time, it will induce colitis, some studies have shown that autoimmune factors are one of the main factors in the onset of ulcerative colitis.
[patent details]: aiming at the problem that the prior art lacks the strain that can eliminate free radicals in the body, the invention provides a bifidobacterium longum JBLC141 that can eliminate free radicals in the body and its application (Huojun No. 1), the bifidobacterium longum JBLC141 can remove excess free radicals in the body, prevent the loss of free radicals to the body cells, alleviate the reduction of SOD activity and the surge effect of GPx activity, and can also play a certain protective role in cell oxidative damage, and alleviate the fatigue of the body. In practical application, the addition of Bifidobacterium longum JBLC141 not less than 5 billion CFU per bag, 2 to 3 sachets per day, will greatly eliminate free radicals in the body, greatly reduce the risk of free radicals to human health, and help the recovery of ulcerative colitis, prevent recurrence and cancer.
[Related research]: Professor Nie Shaoping of Nanchang University published a research paper in the Journal of Food Science, in-depth discussion of the potential of Bifidobacterium longum in the alleviation of colitis, especially the impact of different intestinal microbiota backgrounds on its effect. The study provides new possible avenues for the treatment of ulcerative colitis.
Further investigation found that Huojun No. 1 is a probiotic formulated by its founder for the mother's colitis high-end customized ulcer patent strain formula, which has been passed down for three generations and is more accurate; In addition to the above three invention patent strains, Lactobacillus paracasei JLPF-176 which "inhibits Helicobacter pylori infection" and Lactobacillus acidophilus JYLA-191 which "reduces blood cholesterol content" are also added, which also have good nutritional and health effects on stomach and blood pressure, blood lipids and blood sugar; The star strain of Bifidobacterium juvenileum bbf-06 combined with Lactobacillus acidophilus JYLA-191 has been confirmed by many hospital clinical trials that it can effectively maintain the remission of experimental colitis, help restore normal weight and health, inhibit or kill pathogenic bacteria, and rebuild the intestinal microecological environment is conducive to the continuous remission of ulcerative colitis (see Chinese Journal of Digestion, Issue 7, 2008 for details).
It is reported that the colitis of the founder of Huojun No. 1 has been fully recovered for many years under the combination of drugs and the health management of dietary structure, lifestyle, psychology and emotion, etc., and has not taken medicine for many years. The mother also wanted other people with bad stomachs to benefit, so she put it on the market. Huojun No. 1 is also one of the original powder probiotics on the market, no food accessories, no food additives, no allergenic substances, pure raw powder, no dilution, the real content of six live bacteria is not less than 50 billion, which is equivalent to Moutai's original puree wine, which is extremely noble.
The children also specially consulted their father's attending physician, and the doctor also praised this probiotic after seeing the formula of Huojun No. 1, but it is a probiotic with a food name, and cannot replace drug treatment. In addition, probiotics improve the structure of intestinal flora, restore the healthy balance of intestinal flora, repair the bacterial membrane barrier that protects the intestinal mucosa, and reshape and stabilize the intestinal immune system.
With the doctor's approval, the children immediately bought nine boxes of thanksgiving packs for their father at the "Jingdong Huojun No. 1 Flagship Store", comforted their father's emotions, encouraged their father to adhere to drug treatment and live bacteria to nourish the intestines, and combined with dietary structure, lifestyle, psychological and emotional recuperation.
The miracle really appeared, less than a month, Lao Wang's mucus and blood disappeared, three months later, the stool mucus also disappeared, the stool returned to normal once a day, the appetite was particularly good, the weight slowly returned to normal, the spirit was also very good, Lao Wang's mood was happy, full of confidence, more conducive to the recovery of the disease, forming a virtuous circle, half a year later, Lao Wang went to the hospital for a re-examination of colonoscopy, the results showed that the whole colon was not abnormal, which means that Lao Wang's ulcerative colitis for more than ten years has achieved clinical cure, under the guidance of doctors, Lao Wang gradually stopped the drug and continued to insist on supplementing Huojun No. 1 Hexalive bacteria.
As of today, under the filial piety of his children, Lao Wang insisted on eating Huojun No. 1 to nourish his intestines for more than a year, not only his stomach was very comfortable, and there were no signs of recurrence, but his blood pressure and blood lipids were very stable, and he felt that he was getting younger and happier the more he lived. Lao Wang thought to himself, I was really wronged, I ate so many brands of domestic probiotics and imported probiotics, but none of them were exclusively for ulcerative colitis, and none of the probiotics had invention patents and clinical control experiment reports for improving ulcerative colitis.
(Author's statement: This article is for informational purposes only.) ）