Not all probiotics work! To improve ulcerative colitis, you need to look for the Chinese invention patent certificate!
Lao Wang has been suffering from ulcerative colitis for more than 10 years, from frequent diarrhea and irritable bowel symptoms in the early stage of enteritis, to the gradual evolution of colitis, until ulcerative colitis, the pain has been aggravated, he has visited famous doctors, tried Western medicine, Chinese medicine, health products, probiotics and countless other therapies. However, although the drug provides temporary relief, the symptoms recur when the drug is stopped, and the condition becomes more severe. Some doctors say that the cause of this disease is unknown, and long-term medication is needed to control the symptoms and prevent deterioration. However, long-term medication is not a long-term solution, is there really no solution to this disease? Lao Wang is struggling to find an answer in his illness?
In recent years, probiotic medical technology has made significant progress, and the world's expectations for the eradication of ulcerative colitis have been pinned on the field of probiotics.
Nature Reviews Microbiology, the world's top medical journal, clearly points out that probiotics play a pivotal role in the human body, they control about 70% of the immune system, participate in the digestion and absorption of 95% of nutrients, and excrete about 80% of toxins, becoming the key link connecting the human body's "brain-gut axis" nervous system and the entire metabolic system. Probiotics inhibit harmful factors such as bacteria, viruses, parasites, and pathogens in the intestine, effectively prevent them from invading the intestine, and build a solid "bacterial membrane barrier" on the surface of the intestinal mucosa, which has the triple protection effect of "chemical barrier, biological barrier and immune barrier" to ensure intestinal health and avoid the occurrence of enteritis.
Whether genetic, infectious, environmental, psychiatric, or autoimmune, the onset of ulcerative colitis often begins with an imbalance in the intestinal flora. In this process, harmful bacteria gradually take over, releasing large amounts of toxins, resulting in a large amount of free radicals in the intestines. These free radicals attack normal immune cells, causing them to malfunction, which in turn attacks the cells of the intestinal mucosa, triggering an inflammatory response. At the same time, the mutual attack of immune cells will also exacerbate the immune response, resulting in a series of symptoms such as congestion, edema, ulceration, bleeding, and erosion of the intestinal mucosa. In order to curb the occurrence of ulcerative colitis at the source, supplementing with probiotics with specific functions such as "improving ulcerative colitis" and "scavenging free radicals in the human body" has become an ideal treatment method.
In mainland China, many doctors also actively recommend probiotic supplementation for patients with enteritis, and prescribe probiotics with "drug quasi-brand", such as Bifidobacterium quadruple viable tablets, lactobacillus tablets, Bacillus subtilis double viable granules, Bacillus licheniformis, etc. However, due to the fact that most of the production batch numbers of these "quasi-brand" probiotics were concentrated before 2006, the strains were relatively single, and there were still doubts about their safety, and they needed to be taken under the guidance of doctors. In addition, the technical indicators such as strain function, activity, and content of these probiotics often lag behind those of some high-end brands of colitis probiotics on the market, so their therapeutic effect is limited.
In recent years, probiotic medical technology in mainland China has made rapid progress. However, due to the lengthy approval process required to apply for the "drug approval brand", including phase III clinical trials and nearly 10 million yuan of R&D investment, 99% of the probiotic products on the market are food brands. The prices of these products are uneven, ranging from tens of yuan to hundreds of yuan, and the quality is also uneven. Faced with a wide variety of probiotic products, consumers often have a hard time making a choice. Take Lao Wang as an example, he tried several brands of probiotic products because he was greedy for cheapness, but the results were not satisfactory. Although his children bought expensive imported probiotics for him, they also failed to achieve the desired therapeutic effect.
In fact, probiotics can only fight against harmful bacteria and thus improve the structure of the intestinal flora by reaching the intestines alive and colonizing the intestines. However, probiotics are low-end microorganisms and have extremely high requirements for the living environment. The strains of bacteria in the intestines of foreigners are not necessarily suitable for the living environment of the Chinese intestines. In addition, probiotics imported from abroad will face the problem of loss of activity during long-distance transportation. Therefore, many people in the industry do not recommend the consumption of imported probiotics.
For Lao Wang, ulcerative colitis has been plagued for years. The long-term use of Western medicine and Chinese medicine not only made his appetite worse, but also gradually lost his body and his mental condition deteriorated. Not only did he have to endure the pain of gastrointestinal discomfort, but he was also worried about the risk of cancer, and regularly went to the hospital for follow-up colonoscopies. This kind of pain and trouble made Lao Wang's temper become more and more irritable, and he often complained and got angry with his family for no reason. However, his sons and daughters sought a new cure for ulcerative colitis for him with filial piety.
After years of experience accumulation and lessons learned, Lao Wang's children did not blindly buy probiotic products for him. They first went to the Patent Office of the State Intellectual Property Office to inquire about the patent numbers and patent details of the three invention patent strains related to ulcerative colitis, the clinical control test report, and the relevant qualification procedures, formulas, and user feedback of the application product "Huojun No. 1". After in-depth research and understanding, they chose this probiotic product with significant curative effect for Lao Wang. Eventually, Wang's health improved dramatically, and his life was restored.
Patented strain 1: Huojun No. 1 star strain Lactobacillus reuteri JYLB-291
[Invention Name]: A Lactobacillus reuteri JYLB-291 to improve ulcerative colitis and its application (Huojun No. 1)
[Patent No.]: ZL 2021 1 1566079.0
[Certificate No.]: No. 4950492
[Patent details]: In view of the current lack of probiotics with good treatment effect on human ulcerative colitis, the present invention provides a JYLB291 of Lactobacillus reuteri to improve ulcerative colitis and its application (Huojun No. 1), the strain is derived from the feces of healthy adults in China, which is consistent with the application object, and the specificity and effectiveness of the strain to the body's probiotic function are stronger, and it is more suitable for Chinese constitution; When applied, this strain can effectively tolerate gastric acid and bile salts, and colonize the intestine to improve the intestinal microflora and improve the environment for the development of diseases, regulate the balance of pro-inflammatory and anti-inflammatory factors, and thus play a role in improving ulcerative colitis.
[Clinical Trial]: A total of 100 patients with ulcerative colitis whose main symptoms were fecal mucus and pus and blood, abdominal pain, increased stool frequency or loose stools, including 48 males and 52 females, were selected. They were divided into control group and experimental group, with 50 cases in each group. Experimental group: 25 males, 25 females, age 20 ~ 65 years, average age 45.8 years, disease duration 1~10 years, average disease duration 4.8 years, 42 cases with fecal mucus, pus and blood, 35 cases of abdominal pain, 50 cases of increased stool frequency, 47 cases of loose stool.
The experimental group was treated with mesalazine (content 0.4g), 2 tablets/time, 3 times a day; and take Lactobacillus reuteri JYLB291 once daily at a dose of 1×108 cfu/kg body weight.
The treatment time was 30 days, and it can be seen that the treatment effect of the four most typical symptoms (stool mucus and blood, abdominal pain, increased stool frequency, loose stool) was significantly improved after adjuvant treatment with Lactobacillus reuteri JYLB291 1×108 cfu/kg bw/day, and the effective rate was up to 95.7%. In practical application, the JYLB291 of Lactobacillus reuteri added to each bag of Huojun No. 1 is not less than 10 billion cfu, which is much higher than the clinical control test dose of 1×108 cfu/kg body weight.
[Related research]: In the academic journal "Modern Digestive and Interventional Diagnosis and Treatment", Vol. 24, No. 12, 2019, a literature entitled "Probiotic Characteristics of Lactobacillus reuteri and Research Progress in the Treatment of Ulcerative Colitis" has attracted widespread attention. This article discusses in depth the outstanding performance of Lactobacillus reuteri in inhibiting harmful bacteria, regulating intestinal flora, enhancing immune function and improving mucosal barrier, especially in the prevention and treatment of ulcerative colitis.
Professor Hu Naiwen from the Department of Rheumatology and Immunology of Shandong Provincial Hospital further pointed out that Lactobacillus reuteri can not only activate intestinal immune cells and improve the body's ability to resist diseases, but also promote the digestion and absorption of food and reduce the risk of gastrointestinal diseases. In addition, it also has antioxidant function, which can effectively scavenge free radicals and reduce the damage of oxidative stress to the body.
专利菌株二、活君一号明星菌株干酪乳杆菌L.Casei21
[Invention Title]: A Lactobacillus casei L.Casei21 with therapeutic effect on diarrhea and its application (Huojun No. 1)
[Patent number]: ZL 2021 1 0242478.5
Certificate No.: No. 4446831
[Patent details]: In view of the drug resistance and adverse reactions that may be caused by drug treatment, the present invention provides a kind of Lactobacillus casei that has a therapeutic effect on diarrhea. Casei21 and its application (Huojun No. 1), good resistance to gastric acid and bile salts, and strong ability in cell colonization. Casei21 itself can greatly reduce the adhesion effect of pathogenic bacteria, and its metabolites also have a good antibacterial effect on the three pathogenic bacteria of diarrhea, after taking the bacterium can enter the intestine through the digestive tract, inhibit the pathogenic bacteria, and colonize the intestine, maintain the balance of environmental flora, can effectively inhibit the occurrence of diarrhea, improve diarrhea symptoms, and reduce the risk of diarrhea recurrence.
[Clinical trial]: 100 patients with symptoms such as abdominal pain, diarrhea, frequent bowel movements, and warmth in limbs were selected and divided into control group and experimental group, with 50 people in each group, and the trial was conducted for 30 days. During the trial, each patient's living and eating habits remained unchanged, and they all took trimethyl maleate pudding tablets once a day according to the doctor's instructions, and the experimental group took an additional 15 billion Lactobacillus casei L after taking trimethyl maleate tablets for 2 hours. Casei21 once. After 30 days, the efficacy was observed and statistics, and the statistical results are shown in the following table. Casei21 and its products have a clear positive therapeutic effect on patients with diarrhea, with an overall response rate of up to 92%. In practical application, Huojun No. 1 is added with no less than 10 billion cfu per bag of Lactobacillus casei L.Casei21, 2 to 3 bags per day, which is higher than the clinical control test dose of 15 billion.
[Related research]: Professor Qi Dianjun of the First Affiliated Hospital of China Medical University also emphasized that Lactobacillus casei can not only provide the human body with necessary nutrients, enhance nutrient metabolism, but also promote digestion, prevent constipation, further improve intestinal function, and enhance individual physique. More studies have shown that Lactobacillus casei combined with conventional treatment can significantly alleviate the clinical symptoms of patients with ulcerative colitis, with significant efficacy and high safety, which provides a new treatment idea for clinical practice.
Patented strain 3, Huojun No. 1 star strain Bifidobacterium longum JBLC-141
[Invention Title]: A Bifidobacterium longum JBLC-141 that can eliminate free radicals in the body and its application (Huojun No. 1)
【专利号】：ZL 2021 1 0227019X
[Certificate number]: No. 4622441
[Pain point needs]: The theory of free radicals believes that free radicals are the source of all diseases and the main culprits of human immune diseases, aging and tumors. Free radicals attack healthy cells to become senescent cells or cancer cells, free radicals attack immune cells, making normal immune cells abnormal, immune cells attack each other, abnormal immune cells will also attack intestinal mucosal cells, over time, it will induce colitis, some studies have shown that autoimmune factors are one of the main factors in the onset of ulcerative colitis.
[patent details]: aiming at the problem that the prior art lacks the strain that can eliminate free radicals in the body, the invention provides a bifidobacterium longum JBLC141 that can eliminate free radicals in the body and its application (Huojun No. 1), the bifidobacterium longum JBLC141 can remove excess free radicals in the body, prevent the loss of free radicals to the body cells, alleviate the reduction of SOD activity and the surge effect of GPx activity, and can also play a certain protective role in cell oxidative damage, and alleviate the fatigue of the body. In practical application, the addition of Bifidobacterium longum JBLC141 not less than 5 billion CFU per bag, 2 to 3 sachets per day, will greatly eliminate free radicals in the body, greatly reduce the risk of free radicals to human health, and help the recovery of ulcerative colitis, prevent recurrence and cancer.
[Related research]: Professor Nie Shaoping of Nanchang University published a research paper in the Journal of Food Science, in-depth discussion of the potential of Bifidobacterium longum in the alleviation of colitis, especially the impact of different intestinal microbiota backgrounds on its effect. The study provides new possible avenues for the treatment of ulcerative colitis.
After in-depth research, we found that this probiotic product is a patented strain formula carefully developed by its founder for the mother's colitis. This probiotic formula has not only been passed down and optimized for three generations to make it more precise to meet the needs of treatment, but also contains a deep sense of filial piety behind it. At any cost, Huojun No. 1 has selected a variety of high-cost star strains, including three patented strains, and additionally added Lactobacillus paracasei JLPF-176, which has the effect of "inhibiting Helicobacter pylori infection", and Lactobacillus acidophilus JYLA-191, which can "reduce blood cholesterol content", these two strains not only have significant nutritional and health effects, but also have a good regulatory effect on stomach and blood pressure, blood lipids, blood sugar, etc.
In particular, it is worth mentioning that the combined application of the star strain Bifidobacterium juvenile bbf-06 and Lactobacillus acidophilus JYLA-191 in the formula has been verified by clinical trials in many hospitals, and has been proven to be effective in relieving the symptoms of experimental colitis, helping patients return to normal weight, inhibiting or killing pathogenic bacteria, and rebuilding the intestinal microecological environment, thereby facilitating the continuous remission of ulcerative colitis. This achievement was reported in detail in the 7th issue of the Chinese Journal of Digestion in 2008.
It is reported that after the mother of the founder of Huojun No. 1 insisted on using Huojun No. 1 and cooperated with a reasonable diet, lifestyle and psychological and emotional management, the colitis condition has fully recovered for many years and no longer needs to rely on drug treatment. The mother felt the benefits of Joy One and wanted other people with gastrointestinal discomfort to benefit as well, so she introduced it to the market.
As a rare raw powder probiotic product on the market, Huojun No. 1 has the unique advantage of not adding any food excipients, food additives and allergenic substances, ensuring the purity and safety of the product. In each box of Huojun No. 1, the true content of six live bacteria is not less than 50 billion, which is as noble as Moutai's original puree wine.
When the children of the founder of Huojun No. 1 learned about this product, they specially consulted their father's attending physician. After consulting the formula of Huojun No. 1, the doctor also spoke highly of it. However, the doctor also emphasized that although Huojun No. 1 is a high-quality probiotic product, it belongs to the food category and cannot replace drug treatment. In the process of treatment, the drug treatment of the hospital should be the mainstay, supplemented by Huojun No. 1, and the two complement each other. At the same time, patients should also pay attention to the adjustment of dietary structure and lifestyle, avoid eating raw, cold, spicy and irritating foods, maintain small and frequent meals, regular and quantitative eating habits, and pay attention to the combination of work and rest, and maintain a healthy psychological mood.
At the doctor's suggestion, the sons and daughters of the founder of Huojun No. 1 immediately bought nine boxes of thanksgiving packs for their father to use at the "Jingdong Huojun No. 1 flagship store". After a period of consistent use, a miracle really happened. In less than a month, Lao Wang's mucus and bloody stool symptoms have been significantly improved; After three months, the stool mucus also disappeared, the stool returned to normal once a day, the appetite increased greatly, and the weight gradually returned to normal. Lao Wang's mental state is also getting better and better, his mood is happy, and his confidence is doubling, which undoubtedly plays a positive role in promoting his recovery.
Half a year later, Lao Wang went to the hospital for a follow-up colonoscopy, and the results showed that there was no abnormality in the whole colon, which means that his ulcerative colitis for more than ten years has achieved clinical cure. Under the guidance of the doctor, Lao Wang gradually stopped the drug, but he still insisted on supplementing Huojun No. 1 Hexalive bacteria. So far, under the filial piety of his children, Lao Wang has insisted on using Huojun No. 1 to nourish his intestines for more than a year. His gastrointestinal condition has been fine, with no signs of recurrence, and his blood pressure and lipids have remained stable. Lao Wang said with emotion: "I used to eat so many brands of domestic probiotics and imported probiotics, but none of them were exclusively for ulcerative colitis. Now that I have the Living Monarch No. 1, it's really a blessing for me! ”
(Author's statement: This article is for informational purposes only.) ）