The COVID-19 mutant Strain Omicron you don't know and need to know the things!

This variant was first detected in South Africa on 9 November 2021. On November 26, 2021, the World Health Organization defined it as the fifth "concerned strain," named the Greek letter Omicron. On November 29, the overall risk assessment of the new coronavirus Amickon variant was "very high" and could spread widely around the world. The World Health Organization recently issued another warning: Omi kerong is spreading at an unprecedented rate.

1) Why does Amikeron spread so quickly?

The Omiljunn variant shows that there are more than 30 mutations that cause amino acid changes in the spike sequence, 15 of which are located in the receptor-binding domain (RBD), which is the key ACE-2 receptor for the virus's interaction with cells. The researchers inferred from O's spikes to determine the transmission rate gene sequence and found that a group of mutations at the S1-S2 furin lysis site may enhance viral infectivity, and RBD will produce a high binding affinity with the human ACE2 of this variant. Objectively speaking, it is the vaccination coverage and vaccination rate in South Africa that have led to the emergence of this variant, and there is even a trend to replace the Delta variant.

2) Will the existing detection methods not be able to find Out Amy Kerong?

The performance of the RT-PCR test (NAAT test) is not affected by this new variant, but testing against at least two different genomic regions of the SARS CoV-2 sequence is important to prevent false negatives due to a major change in one of the targets. For the E484K/Q, L452R, N501Y, a number of mutation-specific test detections have been offered, allowing for very rapid implementation of appropriate screening strategies for Aumechon.

Viral antigen testing may be affected by the detection of some mutations in the Oplet sequence of the Omikeron nuclear capsid.

3) Will the Opichron variant cause more severe cases of COVID-19?

The current global retrospective analysis suggests that the first infection in Aumechjong may follow. Some believe that this new variant will lead to milder cases, while others believe that it will lead to more severe cases, especially in children. In fact, when looking at the severity and mortality of COVID-19, we should pay attention to the overall response attitude of the country, especially the vaccination rate and demographic characteristics, including indicators such as age, socio-economic level, medical management level, and even health system saturation.

4) Can the current COVID-19 vaccine still prevent the Omilon mutation?

It has been reported in the news that vaccinated and unvaccinated people are infected with the Aomi Kerong variant virus. This stems from the fact that the virus may have mutations in different numbers and sequences, which may evade fluid and cell-mediated immune responses, which are provided by vaccination. Theoretically, the deletion of the S gene or the failure of the S gene targeting is the cause of the complete failure of the vaccine, which was not detected in the PCR test of the Omi kerong sample. This requires scientists to interpret the sequence of variantSmikron faster, which will help discover and develop vaccines and diagnoses. It is believed that only time and surveillance can give us more information about the transmissibility, the efficacy of vaccines and the severity of the disease caused by this new variant. We can already be sure that protective measures vaccination remain a key factor in stopping the spread of new variants and preventing disease. (Image from the Internet)